15-trien-17,2-olide

The first fermentation was accomplished in dark conditions at 25°C. The resulting active organic extract (mycelial and broth) (IC50 = 195-0 Xg/ml against A. hypochondriacus) yielded 1-hydroxy-2-oxoeremo-phil-l(lO), 7(11), 8(9)-trien-12(8)-olide (58), a novel natural product and penicillic acid (59), a known phytotoxin (Fig. 18). ... 

The structure of 58 was elucidated as 1-hydroxy-2-oxoeremophil-1(10),7(1 l),8(9)-trien-12(8)-olide. This proposal was corroborated by an X-ray analysis. Finally, the absolute configuration of compound 58 was proposed as depicted on the basis of the CD spectrum which displayed a strong negative Cotton effect on 378 nm. Furthermore, as (-) ligu-larenoHde, whose absolute stereochemistry was determined by chemical correlation, compound 58 possesses a negative optical rotation. 

Sql 04 2-Oxo-8p-methacryloyloxy-guaia-1 (10),3,11(13)-trien-6a,l 2-olide V. gardneri NFkB... 

Keto-8a-hydroxy-5a-6a-7pH-guaian-1(10),3(4),11 (13)-trien-6,12-olide 153 ov ) OH T. vulgare 16... 

Other abietane derivatives with benzenoid ring C are among the active substances in some well-known medicinal herbs. The parent hydrocarbon (-)-8,l 1,13-abieta-triene occurs in the pine tree Pinus pallasiana (Pinaceae). (+)-Camosolic acid and the 20,7p-lactone (-olide) of its hydroxy-derivative referred to as camosol belong to the bitter substances of the oil of sage from Salvia camosa (Labiatae) and related species. (-)-Rosmanol, a 20,6p-lactone, is an antioxidant isolated from the leaves of rosemary Rosmarinus officinalis (Labiatae), which also contain camosol. 

Epoxy-1,2,4,8-tetrahydroxy-18,19-dinor-13( 16), 14-clerodadien-17.12-olide, E-30109 / -Mentha-1,3,5-triene-2,5,8,9,10-pentol 9-Tigloyl, 2-Me ether, 10-Ac, in M-10030... 

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