Trichoharzin

Trichoharzin (83) has been isolated from a culture of a strain of T. harzianum found on the fresh marine sponge Micale cecilia [103]. Cultivation of the strain in either fresh water medium or salty water medium gave significantly different profiles of metabolites. Extraction of the salty water medium yielded 83. This compound is probably an octaketide which has undergone a putative Diels-Alder reaction (Scheme 13) similar to that presumed to occur in the biosynthesis of lovastatin, a... 

Trichoderma harzianum Rifai (Hypocreaceae) is a widespread soil Ascomycotina known to produce antibiotics active against other microscopic fungi. This species was found in a sponge Mycale cecilid) collected in Japan. The strain, when cultured in seawater, proved capable of producing substances different from those obtained in freshwater medium, including trichoharzin (38) (a colorless glassy solid identified by MS, NMR spectroscopy and chemical conversion extraction yield 0.5 mg/1), which is a new oktaketide with a decalin fi-amework [79]. 

The polyketide trichoharzin (38) was only produced when Trichoderma harzianum was cultured in a salt-free medium [79]. 

Trichoharzin and deoxynortridioharzin are two original polyketides isolated from a adture of two different fimgi obtained from two different sponges, themselves collected from different ocean areas. Trichoharzin comes from the culture of the species Trichoderma harzianum taken from the sponge Mycale cecilia of Amami Island, Japan (Kobayashi... 

Trichoharzin (R = CH2OH) Trichoderma harzianum/Mycale cecilia Kobayashi et al., 1993 Deoxynortrichoharzin (R = H) Paedlomyces sp./Jaspis coriacea Rahbaek et at, 1998... 

Kobayashi, M., Uehara, H., Matsunami, K, Aoki, S., and Kitagawa, I. (1993) Trichoharzin, a new polyketide produced by the imperfect fungus Trichoderma harzianum separated from the marine sponge Mycale Cecilia. Tetrahedron Lett., 34, 7925-7928. 

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