Trichoharzin from Trichoderma harzianum

Trichoharzin and deoxynortridioharzin are two original polyketides isolated from a adture of two different fimgi obtained from two different sponges, themselves collected from different ocean areas. Trichoharzin comes from the culture of the species Trichoderma harzianum taken from the sponge Mycale cecilia of Amami Island, Japan (Kobayashi... 

Kobayashi, M., Uehara, H., Matsunami, K, Aoki, S., and Kitagawa, I. (1993) Trichoharzin, a new polyketide produced by the imperfect fungus Trichoderma harzianum separated from the marine sponge Mycale Cecilia. Tetrahedron Lett., 34, 7925-7928. 

Trichoderma harzianum Rifai (Hypocreaceae) is a widespread soil Ascomycotina known to produce antibiotics active against other microscopic fungi. This species was found in a sponge Mycale cecilid) collected in Japan. The strain, when cultured in seawater, proved capable of producing substances different from those obtained in freshwater medium, including trichoharzin (38) (a colorless glassy solid identified by MS, NMR spectroscopy and chemical conversion extraction yield 0.5 mg/1), which is a new oktaketide with a decalin fi-amework [79]. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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