Jaspis coriaceae

The salt-water culture of Aspergillus ochraceus separated from the Indo-Pacific sponge Jaspis coriacea has yielded two new chlorine containing polyketides, chlorocarolide A (183) and B (184). These compounds have an overall structural analogy to penicilic acid whose biosynthesis has been intensely studied. The structures and stereochemical features of the chlorocarolides were reported [214]. 

Trichoharzin (R = CH2OH) Trichoderma harzianum/Mycale cecilia Kobayashi et al., 1993 Deoxynortrichoharzin (R = H) Paedlomyces sp./Jaspis coriacea Rahbaek et at, 1998... 

Jaspidae Quinoa eta ., 1986 Jaspis carter . D Auria eta ., 1997 Jaspissp. Groweiss eta ., 1999 Pachastrissa sp. Fernandez eta ., 1999 Jaspis coriacea Thale etai., 2001 Figure 19.41 Bengamides ofJaspis and Pachastrissa. 

Two diastereoisomer chlorhydrins, chlorocarolides A and B, were isolated from the culture of an Aspergillus associated with the Indo-Pacific sponge Jaspis cf coriacea, along with other similar lactones, but nonchlorinated and already known, such as mellein, penicillic acid and hex-ylitaconic acid, although there was no mention of their optical activity (Abrell, Borgeson, and Crews, 1996a). 

Chlorocarolide A (7R, SR) Chlorocarolide B (7S, 8S) Aspergillus sp./Jaspis cf. coriacea Abrell, Borgeson, and Crews, 1996a... 

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