Trichloromethane toxicity

One of the chief uses of chloromethane is as a starting material from which sili cone polymers are made Dichloromethane is widely used as a paint stripper Trichloromethane was once used as an inhalation anesthetic but its toxicity caused it to be replaced by safer materials many years ago Tetrachloromethane is the starting mate rial for the preparation of several chlorofluorocarbons (CFCs) at one time widely used as refrigerant gases Most of the world s industrialized nations have agreed to phase out all uses of CFCs because these compounds have been implicated m atmospheric processes that degrade the Earth s ozone layer... 

Tetrachloromethane has a higher viscosity than trichloromethane (leading to a greater pressure drop across the column). It is also toxic. 

Note Polar solvent soluble in alcohols, ether, benzene, and most oils usually stabilized with methanol to prevent phosgene formation flammable and highly toxic by inhalation, ingestion, or skin absorption narcotic carcinogenic incompatible with caustics, active metals, aluminum powder, potassium, sodium, magnesium. Synonyms trichloromethane, methane trichloride. 

The Schedule 3 list contains only 17 discrete chemicals, of which four represent toxic chemicals. One of them is too simple (HCN) to produce an informative mass spectrum and some of the precursors (chlorinating chemicals) cannot be analyzed by GC/MS. Mass spectra are contained in the OPCW Analytical Database and in commercially available databases. The mass spectrum of trichloroni-tromethane (chloropicrin, CAS 76-06-2) is almost identical to that of trichloromethane (chloroform), apart from a peak at mlz 30. Not scanning this low... 

The toxic materials may be sohd, liquid, or gas. The sohd toxic materials are radioactive substances and metals such as Pd, Cd, As, Cr, Al, and others in various forms. The chemicals are mostly in liquid and gaseous forms. For example, diethyl bromide, chlorofluoro carbons (CFCs), trichlorethane, or trichloromethane are liquids whereas phosgene, chlorine, carbon monoxide, hydrogen cyanide, and isocyanate are gases. 

Chromates and dichromates arc highly toxic and can be cancerogenic. Protective gloves should be worn Trichloromethane is also highly toxic. 

The trichloromethane solutions are transferred to the containers used for collecting halogenated organic solvents, while the small amounts of undissolved salts should be placed in the container used for storing toxic inorganic waste. 

It has long been speculated, since the pioneering work of Muller in 1911 [1459], that phosgene may be an important intermediate in the toxicity of trichloromethane and tetrachloromethane. Experiments on rat liver microsomes have demonstrated that phosgene is generated when CHClj is metabolized both in vitro [1316,1631,1635,1636,1846] and in vivo... 

Trichloroacetic acid (Figure 12.5), also known as trichloroethanoic acid and trichloromethane carboxylic acid, comes in the form of colorless or white crystals and has a distinctive sharp, pungent odor. As far as its toxicity is... 

Substituting a third chlorine on the methane molecule results in the compound whose proper name is trichloromethane. Tri- is for three, chloro- is for chlorine, and methane is for the hydrocarbon s name for the one-carbon chain). It is more commonly known as chloroform. Its molecular formula is CHCI3. Chloroform is a heavy, colorless, volatile liquid with a sweet taste and characteristic odor. It is classified as non-flammable, but it will bum if exposed to high temperatures for long periods of time. It is narcotic by inhalation and toxic in high concentrations. It is an insecticide and a fumigant and is very useful in the manufacture of refrigerants. The total... 

TRICHLOROMETHANE SULFURYL CHLORIDE (594-42-3) Contact with alkalis or amines can cause rapid decomposition. Contact with hot iron or steel produces toxic carbon tetrachloride fumes. Hot water or steam produces hydrochloric acid. Reacts with sulfur and carbon dioxide. Attacks some plastics, rubber, and coatings. Corrosive to most metals. 

Trichloromethane (or chloroform, CHCI3) is non-flammable and was used as an anaesthetic, before it was found to cause liver damage. Tetrachloromethane (or carbon tetrachloride, CCI4) also has anaesthetic properties, but it is even more toxic. Bromochlorotrifluoroethane (common name halothane) is now widely used. It also has anaesthetic properties and is much safer to use. 

Chloroform (trichloromethane) is a chlorinated hydrocarbon solvent used as a raw material in the production of freon and as an extractant and solvent in the chemical and pharmaceutical industry. Because of its hepatic toxicity, it is no longer used as a general anesthetic or anthelmintic agent. Chronic low-level exposure may occur in some municipal water supplies owing to chlorination of biologic methanes (tri-halomethanes). 

Chloroform Trichloromethane, CHCI3. Chloroform is a clear, colorless, volatile, nonflammable liquid with characteristic pungent smell. It is toxic and carcinogenic. Derived by chlorination of methane. Formerly used as an anesthetic, it is now used mainly as a solvent and in organic synthesis to manufacture fluorocarbon plastics and insecticides. 

A colourless, slightly toxic liquid, CH2CI2, b.p. 41°C. It has a characteristic odour similar to that of trichloromethane (chloroform), from which it is made by heating with zinc and hydrochloric acid. It is used as a refrigerant and solvent (for paint stripping and degreasing). 

Chloroform klor-9- form, kl6r- IF chloro-forme, fr. chlor- + formyle formyl fr. its having been regarded as a trichloride of this group] (1838) (trichloromethane) n. CHCI3. A pungent, toxic, dense liquid, useful as a solvent for epoxy resins and others. (2) Clean, colorless, volatile liquid. Sp gr of 1.485 (20/20°C) bp of 61.2°C fp of 63.5°C wt/gal of 12.29 lb (25°C) refractive index of 1.4422 See image). 

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