Triamcinolone acetonide determination

In Figure 3, the active steroid (triamcinolone acetonide) and preservative (benzyl alcohol) are determined from a steroid cream. The higher molecular weight components of the cream base are well separated from the analytes. The ability to elute all the components of a cream or ointment in a SMGPC analysis gives an important sample preparation advantage over competing separation techniques. [Pg.177]

Figure 3. Determination of triamcinolone acetonide and benzyl alcohol from a steroid cream.

FIGURE 5-41. Determination of triamcinolone acetonide (peak A) and benzyl alcohol (peak B) from a steroid cream. Column 500 A Ultrastyragel 7.8 mm ID x 30 cm. Mobile phase THF. Flow rate 1 mL/min. Detection UV, 254 nm, 0.2 AUFS. (Reprinted from reference 13 with permission.)... [Pg.184]

Applying his general method27 h. R. Roberts has worked out quantitative determinations using solvent systems E and F2 (see above). Solvent system F was particularly well suited to quantitate residual triamcinolone. Whatman 1 paper was impregnated with the stationary phase. Triamcinolone acetonide was spot-... [Pg.414]

The plasma levels of triamcinolone acetonide, after intramuscular injection, have been determined, using chloroform extraction, thin layer-chromatography and determination of U.V. absorbance in the presence of fluorescein. or visual comparison to standards. ... [Pg.416]

Jonas et al. (47) performed an uncontrolled study of intravitreal triamcinolone acetonide to treat exudative AMD. Of 71 treated eyes, 68 had predominantly or totally occult CNV, as determined by fluorescein angiography. With a mean follow-up of seven months, the visual acuity increased from a preinjection mean of 0.16 to a maximum of 0.23 (P < 0.001). The maximal visual acuity was attained at 1-3 months postinjection. However, there was no significant visual acuity difference by 7.5 months, when compared with pretreatment visual acuity. The average intraocular pressure (IOP) increased from a baseline of 15.1 to 23.0 mmHg. There were no significant postoperative complications such as endophthalmitis and retinal detachment. [Pg.250]

Santos-Montes, A. Gasco-L6pez, A.I. Izquierdo-Hornillos, R. Simultaneous determination of dexamethasone and betamethasone in pharmaceuticals by reversed-phase HPLC. Chromatographia, 1994, 39, 539-542 [simultaneous dexamethasone methylprednisolone (IS) tablets column temp 30 LOD 6 ng/mL non-interfering corticosterone, cortisone, deflazacort, fludrocortisone, fludrocortisone acetate, hydrocortisone, hydroxyprogesterone, methylprednisolone, prednisolone, prednisone, triamcinolone interfering triamcinolone acetonide]... [Pg.199]

Das Gupta, V. Stability of triamcinolone acetonide solutions as determined by high-performance liquid chromatography. t/.PAarm.Sci., 1983, 72, 1453-1456... [Pg.724]

Koupai-Abyazani, M.R. Yu, N. Esaw, B. Laviolette, B. Determination of triamcinolone acetonide in equine serum and urine by liquid chromatography-atmospheric pressure ionization mass spectrometry. J.Anal.Toxicol., 1995, 19, 182-186... [Pg.1389]

Kedor-Hackmann, E.R.M. Gianotto, E A..S. Santoro, M.I.R.M. Determination of triamcinolone acetonide and salicylic acid in pharmaceutical formulations by high performance liquid chromatography. Phar-mazie, 1996, 51, 63... [Pg.1390]

Gordon, G. Wood, P.R. Determination of triamcinolone acetonide in cream and suspension formulations by high-performance hquid chromatography. Analyst, 1976, 101, 876-882 [simultaneous excipients, prednisolone for trieuncinolone acetonide]... [Pg.1397]

Huopalahti, R.P. Henion, J.D. Application of supercritical fluid extraction and high performance liquid chromatography/mass spectrometry for the determination of some anabolic agents directly from bovine tissue samples, J.Liq.Chromatogr.Rel.TechnoL, 1996,19, 69-87. [UV detection LC-MS cow muscle Uver LOD 100 ppb SPE dexamethasone trenbolone triamcinolone acetonide zeranol diethylstilbe-strol medroxyprogesterone melengestrol acetate]... [Pg.376]

Hammam E (2007) Determination of triamcinolone acetonide in pharmaceutical formulation and human serum by adsorptive cathodic stripping voltammetry. Chem Anal (Warsaw) 52 43-53... [Pg.190]

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