Treatment of anticholinergic intoxication

Relative contraindications to the use of anticholinesterase treatment include a history of cardiovascular disease, asthma, glaucoma, and gastrointestinal or genitourinary obstruction. Symptomatic treatment of tachyarrhythmias with propranolol may be considered P blockers, however, are less effective than physostigmine. 

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Bowen JS, Davis GB, Kearney TE, et al Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion. JAMA 249 1477-1479, 1983 Brands B, Sproule B, Marshman J Drugs and Drug Abuse, 3rd Edition. Toronto, Ontario, Addiction Research Foundation, Fondation de la recherche sur la toxi-comanie, 2001 

Buckholtz NS, Zhou DF, Freedman DX, et al Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain. Neuropsychopharmacology 3 137-148, 1990 

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