Treatment intoxications

Dallocchio C, Mazzarello P. A case of parkinsonism due to lithium intoxication treatment with pramipexole. J Clin Neurosci 2002 9(3) 310-1. 

Bazzano G, Bazzano GS. Digitalis intoxication. Treatment with a new steroid-binding resin. JAMA 1972 220(6) 828-30. 

Engle JP, Polin KS and Stile IL (1987) Acute iron intoxication treatment controversies. Drug Intell Clin Pharm 21 153-159. 

No antidote has been found beneficial, to date, for PCP intoxication. Treatment is symptomatic, and includes careful monitoring of the patient s level of consciousness and their cardiovascular and respiratory functioning. Activated charcoal is indicated if the patient reaches the hospital soon enough. 

This chapter describes the mechanism of toxicity of OPs, intoxication and fatality rates associated with OPs, clinical aspects of OP intoxication, treatment of poisoning, and epidemiological studies of OP poisoning throughout the world. 

P. ipecacuanha, native to South and Central America, is a well-known species used in therapy since the early seventeenth century due to emetic and expectorant activity and later as a medicine for amebic dysentery [98], being widely used as ingredient in pharmaceutical industry. Traditional communities use this plant for intoxication treatment due to its emetic effect [99], as well as stimulant and antidote to opium [100]. 

Qvigstad, T. and Skare, S. (1974) Digitoxin intoxication Treatment with the steroid binding resin cholestyramine (in Norwegian). T. Norske Laegeforen, 94, 1190. 

Vitamin D withdrawal is an obvious treatment for D toxicity (219). However, because of the 5—7 d half-life of plasma vitamin D and 20—30 d half-life of 25-hydroxy vitamin D, it may not be immediately successful. A prompt reduction in dietary calcium is also indicated to reduce hypercalcemia. Sodium phytate can aid in reducing intestinal calcium transport. Calcitonin glucagon and glucocorticoid therapy have also been reported to reduce semm calcium resulting from D intoxication (210). 

Humans tolerate fairly large oral doses of copper without harmful effects, and it is used in various therapies (66). Copper sulfate is a powerful emetic and has been used clinically in the treatment of intoxications. 

The most important fluorinated benzodiazepine, flurazepam (21) has found considerable use (and abuse) as a hypnotic [I4 Flumazenil (22) is a fast-acting antidote in the treatment of benzodiazepine intoxication and m the reversal of the CNS effects of benzodiazepines dunng anesthesia [f<5,19]... 

Principles and recent developments in chelation treatment of metal intoxication 99CRV2683. 

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