Trazodone Digoxin

The effects of buspirone are decreased when the drug is administered with fluoxetine Increased serum levels of buspirone occur if the drug is taken with erythromycin or itraconazole Should any of these combinations be required, the dosage of buspirone is decreased to 2.5 mg BID, and the patient is monitored closely. Venlafaxine blood levels increase with a risk of toxicity when administered witii MAOIs or cimetidine There is an increased risk of toxicity when trazodone is administered with the phenothiazines and decreased effectiveness of trazodone when it is administered with carbamazepine Increased serum digoxin levels have occurred when digoxin is administered with trazodone There is a risk for increased phenytoin levels when phenytoin is administered witii trazodone... 

Drugs that may affect trazodone include carbamazepine, phenothiazines, and venlafaxine. Drugs that may be affected by trazodone include alcohol, barbiturates, CNS depressants, digoxin, MAOIs, phenytoin, and warfarin. 

DIGOXIN TRAZODONE Reports of two cases of t plasma concentrations of digoxin after starting trazodone Uncertain at present Watch for digoxin toxicity check levels and 1 the dose of digoxin as necessary... 

St. John s wort Mild to moderate depression Gastrointestinal upset, photo-sensitivity. Mild serotonin syndrome with the following medications paroxetine, trazodone, sertraline, and nefazodone. May decrease digoxin levels. May decrease cyclosporine serum concentrations. Combined oral contraceptives—breakthrough bleeding. 

Clinically important, potentially hazardous interactions with abacavir, atorvastatin, bepridil, bupropion, carbamazepine, clarithromycin, cyclosporine, dexamethasone, digoxin, felodipine, fluticasone propionate, fosamprenavir, itraconazole, ketoconazole, lovastatin, methadone, midazolam, nicardipine, nifedipine, phenobarbital, phenytoin, rifabutin, simvastatin, sirolimus, St John s wort, systemic lidocaine, tacrolimus, tenofovir, trazodone, vinblastine, vincristine, voriconazole, warfarin, zidovudine... 

Clinically important, potentially hazardous interactions with amitriptyline, amphetamines, aprepitant, astemizole, clarithromycin, dexibuprofen, dextroamphetamine, diethylpropion, digitalis, digoxin, duloxetine, erythromycin, isocarboxazid, linezolid, MAO inhibitors, mazindol, methamphetamine, molindone, phendimetrazine, phenelzine, phentermine, phenylpropanolamine, pseudoephedrine, risperidone, selegiline, sibutramine, St John s wort, sumatriptan, sympathomimetics, tranylcypromine, trazodone, troleandomycin... 

Rauch PK, Jenike MA. Digoxin toxicity possibly precipitated by trazodone. Psychosomatics (1984)25, 334-5. 

A rise in serum digoxin ieveis, accompanied by toxicity in one instance, has been seen when two patients taking digoxin were given trazodone. 

Major drug interactions trazodone interacts with MAOIs with the risk of serotonin syndrome. When switching between trazodone and an MAOI, a 2-week no-trazodone no-MAOI gap is necessary to safely stop and start treatment Trazodone should not be stopped abruptly. Trazodone interacts with alcohol with worsening sedation. Tegretol decreases blood levels while Nizoral and Norvir increase blood levels of trazodone. Co-administration of trazodone can increase blood concentrations of digoxin and phenytoin. Trazodone may also pass into breast milk and affect a nursing baby. 

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