Trazodone Alcohol

Drugs that may affect trazodone include carbamazepine, phenothiazines, and venlafaxine. Drugs that may be affected by trazodone include alcohol, barbiturates, CNS depressants, digoxin, MAOIs, phenytoin, and warfarin. 

Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, diazepam,dicumarofdisulfiram,estrogens, H -antagonists, halothane, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinimides, sulfonamides, tolbutamide, trazodone... 

Trazodone Hydrochloride Trazodone overdose causes severe toxic effects. These effects are severe if taken along with benzodiazepines or alcohol. Trazodone interacts with MAOIs, cardiovascular drugs, CNS depressants, and antiepileptics. 

The death of a 36-year-old patient with a history of alcohol dependence who was taking tramadol, venlafaxine, trazodone, and quetiapine has highlighted the increased risk of seizures with concomitant use of tramadol and selective serotonin re-uptake inhibitors (125). 

Trazodone is perhaps the most sedative antidepressant available, being more sedative than amitriptyline, trimi-pramine, doxepan, or imipramine. Therefore, death has occurred in patients taking trazodone with alcohol, chloral hydrate, diazepam, chlordiazepoxide, meprobamate, or amobarbital. 

Trazodone is used primarily in the treatment of insomnia, mental depression, or depression/anxiety disorders. The drug also has shown some efficacy in the treatment of benzodiazepine or alcohol dependence, diabetic neuropathy, and panic disorders. 

Trazodone can make driving or handling other dangerous machinery more hazardous, particularly during the first few days of treatment, and further impairment may occur with alcohol. 

Another study similarly found that the impairment of psychomotor performance by trazodone was increased by alcohol. This appears to be due to a simple additive depression of the CNS. This is an established interaction, and of practical importance. Patients should be warned that their ability to drive, handle dangerous machinery or to do other tasks needing... 

Two cases of the serotonin syndrome have been reported when tramadol was given with venlafaxine one patient was also receiving mirtazapine. Fatal seizures occurred in an alcoholic man receiving tramadol, venlafaxine, quetiapine and trazodone. 

Major drug interactions trazodone interacts with MAOIs with the risk of serotonin syndrome. When switching between trazodone and an MAOI, a 2-week no-trazodone no-MAOI gap is necessary to safely stop and start treatment Trazodone should not be stopped abruptly. Trazodone interacts with alcohol with worsening sedation. Tegretol decreases blood levels while Nizoral and Norvir increase blood levels of trazodone. Co-administration of trazodone can increase blood concentrations of digoxin and phenytoin. Trazodone may also pass into breast milk and affect a nursing baby. 

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