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Molecule transport

Transporter. A transporter is a protein transporting molecules or ions through the cell membrane against a concentration gradient. [Pg.599]

Pig. 8. Stmctures of (a) hole transporter molecule W,Ar-biphenyl-W,Ar-bis(3-methylphen5l)l-lTiphen5l-4,4 diamine (TPD) (b) an oxidiazole derivative ... [Pg.243]

Fig. 3a. Molecular structures of selected liole-transport molecules. Biphenyls (7a) (R = H)... Fig. 3a. Molecular structures of selected liole-transport molecules. Biphenyls (7a) (R = H)...
The interaction with myosin motors enables F-actin to transport molecules as well as to change or maintain the shape of the cell by exerting tension. Thus, myosin-I motors move to the barbed end and can transport cargoes such as vesicles. When immobilized at the cargo site... [Pg.415]

Neurotransmitter transport can be electrogenic if it results in the net translocation of electrical charge (e.g. if more cations than anions are transferred into the cell interior). Moreover, some transporters may direction-ally conduct ions in a manner akin to ligand-gated ion channels this ion flux is not coupled to substrate transport and requires a separate permeation pathway associated with the transporter molecule. In the case of the monoamine transporters (DAT, NET, SERT) the sodium current triggered by amphetamine, a monoamine and psychostimulant (see Fig. 4) is considered responsible for a high internal sodium concentration... [Pg.839]

The localization of transporter molecules on the cell surface is dynamic rather than constitutive, such that transport capacity may be adapted to neuronal activity. Obviously, the mechanisms regulating uptake are of principal importance in pharmacology just as pharmacological transport inhibitors can regulate the density of transporters. [Pg.840]

Lipinski et al. at Pfizer [11] analyzed the distribution of physicochemical properties of 2245 drugs from the WDI that have entered clinical trials after excluding natural products and actively transported molecules. They proposed the Rule-of-5 to indicate that poor absorption or permeation is more likely when ... [Pg.443]

First, consider the transepidermal route. The fractional area of this route is virtually 1.0, meaning the route constitutes the bulk of the area available for transport. Molecules passing through this route encounter the stratum corneum and then the viable tissues located above the capillary bed. As a practical matter, the total stratum corneum is considered a singular diffusional resistance. Because the histologically definable layers of the viable tissues are also physicochemically indistinct, the set of strata represented by viable epidermis and dermis is handled comparably and treated as a second diffusional resistance in series. [Pg.212]

In Section 7.7.5.4, we discuss the effects of additives in the acceptor wells that create a sink condition, by strongly binding lipophilic molecules that permeate across the membrane. As a result of the binding in the acceptor compartment, the transported molecule has a reduced active (unbound) concentration in the acceptor compartment, cA(t), denoted by the lowercase letter c. The permeability equations in the preceding section, which describe the nonsink process, are inappropriate for this condition. In the present case, we assume that the reverse transport is effectively nil that is, CA(t) in Eq. (7.1) may be taken as cA(t) 0. As a result, the permeability equation is greatly simplified ... [Pg.147]

The second volume starts with biochemistry and new insights into pheromone perception and transport by W. Leal. These findings show that specificity is not only achieved by uniquenss of compounds or blends, but also by the perceiving receptors and transport molecules. The following chapters on bugs... [Pg.3]

Transporter Molecules Responsible lor Hepatic Uptake of Organic Anions... [Pg.289]

G = charge generating molecule T = charge transport molecule... [Pg.565]

This requires the participation of a protein transporter. Molecules move spontaneously toward lower concentration (chemical gradient) and opposite charge (electrical gradient). Moving in the opposite direction requires the input of energy. [Pg.41]


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See also in sourсe #XX -- [ Pg.2 , Pg.448 , Pg.458 , Pg.488 , Pg.491 , Pg.510 , Pg.537 , Pg.567 , Pg.650 ]




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Carbazole charge-transporting molecules

Diffusive transport molecules

GLUT 2 glucose transport molecules

Glycoprotein transport molecules

Guest molecules transport

Hepatic transporter molecules responsible

Membrane Rate-Limiting Transport (Hydrophilic Molecules)

Membranes small molecule transport

Molecule transportation

Molecules, transport across

Molecules, transport across membranes

Neutral molecules, diffusion-limited transport

Penetrant molecule , transport through

Penetrant molecule , transport through copolymers

Penetrant molecules transport

Penetrant molecules transport natural rubber based

Penetrant molecules transport natural rubber based blends

Penetrant molecules transport networks

Penetrant molecules transport properties, absorption

Permeation of large lipophilic molecules—steroid transport

Sialic acids in transport of molecules

Small-molecule-based hole-transport materials

Starburst molecules charge transport of molecular glasses, hole

The Transport Properties of Cross-Conjugated Molecules

The Transport of Molecules through Membranes

Transport carrier molecules

Transport deuterated molecule

Transport materials, small molecules

Transport neutral molecules

Transport of large molecules across the bilayer

Transport of molecules such

Transport of penetrant molecules

Transport of small molecules across the bilayer

Transport of the Molecules

Water Layer Rate-Limiting Transport (Lipophilic Molecules)

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