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Hepatic transporter molecules responsible

Transporter Molecules Responsible lor Hepatic Uptake of Organic Anions... [Pg.289]

The human genome contains nearly 900 genes that encode transporters, of which over 300 are intracellular transporters [1] responsible for transporting a wide range of molecules across the membrane [2]. Further classification of these transporters into families such as the solute carrier dass (SLC) [3] and ATP binding cassette (ABC) family 4, 5] is possible. Transporters play a major role in clinical pharmacology as their adequate bioavailability determines the successful oral delivery of many therapeutics. Membrane transporter proteins are associated with drug absorption (uptake), tissue distribution (efflux and uptake), metabolism (hepatic efflux and uptake), and elimination (renal, biliary transporters, and breast milk efflux and uptake) [6, 7]. [Pg.215]

The liver plays an important role in determining the oral bioavailability of drags. Drag molecules absorbed into the portal vein are taken up by hepatocytes, and then metabolized and/or excreted into the bile. For hydrophilic drugs, transporters located on the sinusoidal membrane are responsible for the hepatic uptake [1, 2]. Biliary excretion of many drags is also mediated by the primary active transporters, referred to as ATP-binding cassette transmembrane (ABC) transporters, located on the bile canalicular membrane [1, 3-5], Recently, many molecular biological... [Pg.288]


See other pages where Hepatic transporter molecules responsible is mentioned: [Pg.278]    [Pg.501]    [Pg.212]    [Pg.94]    [Pg.501]    [Pg.2672]    [Pg.483]    [Pg.366]    [Pg.370]    [Pg.703]    [Pg.252]    [Pg.1419]    [Pg.29]    [Pg.703]    [Pg.77]   
See also in sourсe #XX -- [ Pg.289 ]




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