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Transplantation medicine

The first mouse monoclonal antibody specific for human CD3 was produced in 1979 and named orthoclone OKT3. Aside from its use in the laboratory, OKT3 became the first anti-CD3 antibody to be utilized in transplantation medicine, but its wider application was hampered by its immunogenic and mitogenic properties (reviewed in [6]). Consequently, humanized and engineered anti-CD3 antibodies were developed to circumvent these limitations (Table 1). Since T cells and the TCR are involved in many immunological diseases, it is not surprising that the application of CD3 antibodies is not restricted to the field of transplantation. For example, CD3 antibodies are tested in clinical studies of diseases such as autoimmune diabetes (type 1 diabetes), immune-mediated inflammatory arthritis and inflammatory bowel disease [7]. [Pg.1178]

Figure 1. Natural products which were breakthrough discoveries for transplantation medicine. Figure 1. Natural products which were breakthrough discoveries for transplantation medicine.
In different medical disciplines, highly fluorinated liquids are directly used, like in the case of ocular endotamponades in ophthalmology, of gas carriers in liquid ventilation, or of preservation and transport media in transplantation medicine. For these applications, the highly fluorinated liquids are used in a purified form or as mixtures. The extraordinary... [Pg.421]

This chapter presents the state of the art of the use of highly fluorinated liquids in ophthalmology and perspectives of future applications in the eye. In different medical disciplines, the characteristics of these fluids are directly used, like in the case of ocular endotamponades in ophthalmology, of gas carriers in liquid ventilation, or of preservation and transport media in transplantation medicine [1-3]. For these applications, the highly fluorinated liquids are used in a purified form or as mixtures. The intended effect is created by the physicochemical characteristics themselves. The extraordinary behaviour of the fluorocarbon liquids (FCLs) requires specialised biocompatibility testing, adjusted to this class of components. [Pg.422]

The breakthroughs in modem transplantation medicine are largely attributable to the introduction of ciclosporin. It is now also employed in certain autoimmune diseases, atopic dermatitis, and other disorders. [Pg.306]

The antigen-processing machinery is not yet completely understood. The current interest in antigen processing reflects the importance of the recognition of antigens for transplantation medicine and for an understanding of autoimmune diseases. [Pg.252]

With a greater immunocompromised population caused by HIV, transplantation medicines, and other immrmosuppressive treatments for rheumatoid arthritis (RA), some vaccinations utilizing live vaccines such as the old smallpox vaccine, can be very risky. Society now rmwittingly... [Pg.20]

Data are also available for MS patients, where supplementation with 25(OH)2D3 increased serum levels of antiinflammatory cytokine TGF-J3 after 6 months of treatment, whereas no or little effect was observed on TNF-a, IL-13, IFN-y and IL-2 [187]. No information was given on the clinical presentation of these patients after treatment. In type I diabetes, a long-term study proved dietary vitamin D supplementation was clinically beneficial in terms of reduced risk of the disease [165]. Heart transplant recipients that were treated with low-dose l,25(OH)2D3 aiming at reduction of bone loss required significantly less cyclosporin for prevention of organ rejection suggesting a potentially beneficial immunosuppressive role of l,25(OH)2D3 in transplantational medicine [188]. [Pg.345]

Presently, much interest is focussed on the role of the selectins during inflammation and in transplantation medicine, sinee it was recognized that selectins are involved in the rolling and adhesion of granulocytes to endothelia under the influenee of inflammatory cytokines [1034,1037,1039,1052]. This is a multistep process in which other adhesion... [Pg.364]

In conclusion, our study describes the first estabhshment of pluripotent ES cells from SCNT of a human adult reprogrammed cell and provides the feasibility of using autologous cells in transplant medicine. [Pg.290]

The immunosuppressive drug cyclosporine A (CSA) has revolutionized transplant medicine. However, CSA induced-nephrotoxicity still represents a major therapeutic challenge. Chronic CSA nephropathy is characterized by a decrease in glomerular filtration rate (GFR), tubular atrophy, interstitial fibrosis and progressive renal dysfunction. It is difficult to delineate the mechanisms of CSA toxicity from clinical data since the majority of clinical experiences with CSA have been in renal transplant recipients. Animal models of CSA nephropathy have brought some insights, how-... [Pg.130]

The biogenesis of the amino acids in position 2-11 in C. A proceeds through the usual biosynthetic routes with subsequent /V-methylation by 5-adenosylmethi-onine-dependent methyltransferases. The amino acid in position 1 is built up on the polyketide pathway and subsequently methylated at C-4. It has bron demonstrated that MeBmt is the starter of the non-ribo-somal peptide synthesis by means of a mutant strain of Tolypocladium inflatum Recent clinical data show, that C. application in transplantation medicine significantly increases the risk of cancer . [Pg.167]

C44H69NO12, Mr 804.04, prisms, mp. 127-129°C, [ajj, -84.4° (CHCI3), a macrolactam lactone produced by Streptomyces tsukubaensis, in which a long-chain hy-droxycarboxylic acid is cyclized with L- pipecoUc acid as bridging unit. FK-506 is structurally related to rapamycin and has been prepared synthetically. It exhibits immunosuppressive activity by suppression of cell-mediated and humoral immune responses. It has been available in Japan since 1993, in Europe and USA since 1996 under the name Prograf tacrolimus) for use in transplantation medicine to suppress rejection reactions. FK-506 is also effective in the treatment of autoimmune diseases, e. g., multiple sclerosis, psoriasis, or rheumatoid arthritis. [Pg.231]

C5 H,9N0,3, Mr914.19, cryst., mp. 183-185°C, [aJu -58.2° (CH3OH), a 31-membered peptide lactone in which a long-chain carboxylic acid is cyclized with l- pipecolic acid as a bridge and produced by Strepto-myces hygroscopicus. R. has antifungal, antineoplastic, and immunosuppressive activities, it is structurally related to FK-506 and exhibits a similar mechanism of action in the development of the immune response. R. was first marketed in 1999 in combination with cyclosporin and tacrolimus for use in transplantation medicine. The first total synthesis of R. was realized in 1993. [Pg.543]

Polymer-Based Augmentation of Immunosuppressive Formulations Application of Polymer Technology in Transplant Medicine... [Pg.411]

The decision to undertake Y microembolization should be made following the consent of an interdisciplinary team from interventional radiology, nuclear medicine, radiotherapy, medical and surgical oncology, and transplantation medicine, since a wide variety of conditions and parameters have to be considered (Table 2.7.3). [Pg.75]

I will not end this preface without expressing my gratitude to the individuals who have - voluntarily or not - substantially contributed to making this book happen. I would first like to thank all the authors involved in this work. I strongly believe that the quality of their contributions has made this a comprehensive, informative, and up-to-date contribution to the field of transplantation medicine. I would then like to thank... [Pg.262]


See other pages where Transplantation medicine is mentioned: [Pg.285]    [Pg.300]    [Pg.3]    [Pg.87]    [Pg.441]    [Pg.255]    [Pg.230]    [Pg.78]    [Pg.827]    [Pg.1951]    [Pg.1957]    [Pg.1976]    [Pg.1981]    [Pg.326]    [Pg.451]    [Pg.52]    [Pg.167]    [Pg.2]    [Pg.275]    [Pg.412]    [Pg.414]    [Pg.424]    [Pg.432]    [Pg.434]    [Pg.488]    [Pg.60]    [Pg.96]    [Pg.262]    [Pg.262]    [Pg.262]   
See also in sourсe #XX -- [ Pg.306 ]




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