Transitional cell carcinoma incidence

MOCA was fed to male and female mice for 18 months at a dose of either 1 or 2 g/kg in female mice, but not in males, a statistically significant incidence of hepatoma was observed. In addition, a higher incidence of hemangiosarcomas and hemangiomas was observed in treated animals compared with controls. Urinary bladder tumors (primarily papillary transitional cell carcinomas) occurred in dogs given 100 mg of MOCA by capsule for up to 9.0 years. ... 

Chiou H-Y Chiou S-T, Hsu Y-H, Chou Y-L, Tseng C-H, Wei M-L and Chen C-J (2001) Incidence of transitional cell carcinoma and arsenic in drinking water A follow-up study of 8,102 residents in an arseniasis-endemic area in Northeastern Taiwan. Am J Epidemiol 153 411-418. 

A 2-year carcinogenicity bioassay of tricresyl phosphate in mice and rats showed no evidence of carcinogenicity in these species (NTP 1994). Doses (consumed in feed) were <37 mg/kg/day in mice and < 15 mg/kg/day in rats. Dietary administration of tributyl phosphate was associated with transitional and squamous cell carcinomas of the bladder in rats after 2 years of exposure at 143.3 mg/kg/day (FMC 1994a). An increased incidence of hepatocellular adenomas in the liver was observed in mice after dietary administration of 455 mg/kg/day tributyl phosphate for 18 months (FMC 1994b). 

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