Transgenic mouse models double

Gouqi (Lycium barb arum). Zhang et al. [243] examined the effects of Gouqi (Lycium barb arum) on the learning and memory abilities of an APP/PS1 double transgenic mouse model of AD. Oral administration of Gouqi extracts at 10 mg/kg improved the performance of the APP/PS1 mice in the learning and the memory retrieval phases of the Morris maze and the levels of A()i 2 in hippocampal tissue were reduced. 

Caffeine (0.75-1.5 mg/day) improves memory impairment and the expression of brain neurotrophic derived factor (BNDF) and TrkB in PS1/APP double transgenic mouse models [216]. 

Biradar S, Joshi H, Chheda T (2014) Biochanin-A ameliorates behavioural and neurochemical derangements in cognitive-deficit mice for the betterment of Alzheimer s disease. Hum Exp Toxicol. 33 369-382. Han K, Jia N, Li J, Yang L, Min LQ (2013) Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer s disease. Mol Med Rep 8 737-740. Matsumoto K, Zhao Q, Niu Y, Fujiwara H, Tanaka K, Sasaki-Hamada S et al (2013) Kampo formulations, chotosan, and yokukan-san, for dementia therapy Existing clinical and preclinical evidence. J Pharmacol Sci 122 257-269... 

In one study, PLG microspheres bound to DNA using a cryogenic double emulsion process and injected intramuscularly into mice were found to promote transgene expression for up to 174 days after injection, dependent upon microsphere mass. More recently nanoparticles were constructed from carboxy terminated, PEG modified PGL polymers. These particles were conjugated with an aptamer to the prostate specific membrane antigen and evaluated for in vivo biodistribution in an LNCaP (PSMA+) xenograft mouse model of prostate cancer. In this study, the aptamer caused a 3.77-fold increase in polymer concentration in the tumor tissue after retro-orbital injection (79). 

Brenn A, Grube M, Jedlitschky G, Fischer A, Strohmeier B, Eiden M et al (2014) St John s Wort reduces Beta-amyloid Accumulation in a Double Transgenic Alzheimer s Disease mouse model-role of P-glycoprotein. Brain Pathol. 24 18-24... 

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