Transcription of genetic information

Numerous publications on uracil and thymine and their role in controlling the metabolism, reproduction, and growth of living systems — in particular in the transcription of genetic information and biosynthesis of proteins — have already appeared in the literature. Therefore, these two important pyrimidines will not be discussed again in the present review. Some pertinent literature references are provided [244—264]. 

Frame-Shift Mutation A change in the structure of DNA such that the transcription of genetic information into RNA is completely altered because the start point for reading has been altered i.e. the reading frame has been altered. 

It is well established that actinomycin D inhibits DNA-directed RNA synthesis by binding to guanosyl residues in the DNA molecule. This disrupts the transcription of genetic information and thereby interferes with the production of essential proteins. DNA synthesis may also be inhibited, being reduced by 30% to 40% in utero. It is clear that in the initial stages of embryogenesis, synthesis of RNA for protein production is vital, and it is not surprising that inhibition of this process may be lethal. 

Nucleic acids are known to be responsible for the storage and transcription of genetic information in living cells and are involved in protein synthesis. Nucleic acids are polymers of nucleoside phosphates and hence negatively charged in neutral solutions. Nucleic acids interact strongly with metal ions. Such an interaction with metal ions helps to maintain the conformational stability of nucleic acids and their function. The formation of a complex... 

It was therefore considered [12] that the analogues may produce a mutagenic effect by incorporation into RNA. In this case, the transcription of genetic information from chromosomal DNA to an RNA intermediate, and thence to newly synthesised DNA by a reverse transcriptional process, would seem necessary to explain this type of mechanism. 

We need to clarify one important point in the transcription of genetic information discussed above. This has to do with the precise sequence of bases in DNA that is transcribed into mRNA and then translated into a protein or group of proteins. Organisms are classified into two broad categories, those whose cells contain a nucleus, called eucaryotes, and those whose cells do not have a nucleus, called... 

Gk)ldberger and Berberich (1965) represented these two possible alternatives of transcription of genetic information as applied to the histidine operon in the form of the following scheme (Fig. 

Consequently, RNA synthesis by the bacterial chromosome is a basic element in the transcription of genetic information, and the distribution of sites of this synthesis along the chromosome, as well as in time during the cell cycl is a mechanism controlling the vital activity of the cell. 

Collier, J. R. (1966). The transcription of genetic information in the spiralian embryo. Current Topics Develop. Biol. 1, 39-59. 

---