Trans-resveratrol absorption

Trans-resveratrol (trans-3,5,4 -trihydroxystilbene) is a non-flavonoid polyphenol found in grapes, mulberries, and other food prod-ucts. It is responsible for the antioxidant activity of red wine. Intake of moderate amount of red wine has been found to reduce the risk of cardiovascular diseases. In addition to antioxidant activity, resveratrol could inhibit platelet aggregation, and showed anticancer activity. The phenoxyl radicals of resveratrol produced during oxidation by hydroxyl radicals, one-electron oxidants, and peroxyl radicals showed absorption maximum at 410 nm (Fig. I). Reports indicate that trans-resveratrol is a better radical scavenger than vitamins E and C and its activity is similar to that of the flavonoids epicatechin and quercetin. From the comparison of the spectral and kinetic properties of the transients derived from trans-resveratrol and its analogues, it could be concluded that in the neutral and acidic solutions, the para-hydroxy... 

Absorption of trans-resveratrol and other related compounds in rats was investigated [36]. Male Wistar rats (350 g) were used in a bioavailability study of [ H]trans-resveratrol administered by gavage together with (+ )-catechin, quercetin, and unlabeled trans-resveratrol in matrices of 10% ethanol, V8 vegetable homogenate mixture, and white grape juice. Whole blood, blood serum, urine, feces, and tissue... 

In evaluation of the response of living organisms to resveratrol, it is important to determine the capacity of gastrointestinal absorption and the distribution of resveratrol to various target tissues as well as its metabolism. The bacterial microflora in the ileum and cecum plays an important role in the metabolism and absorption of resveratrol. Kinetics of trans- and civ-resveratrol (3,4, 5-trihydroxystilbene) after oral administration of red wine in rats showed that a fraction of resveratrol (6.5mg/l) was absorbed by rats and can be detected in considerable concentrations in plasma. Peak tissue concentrations recorded at cardiac tissue, liver, and kidneys.A recent study reported albmnin as one of the plasmatic carriers of resveratrol. Interaction of resveratrol with albumin is essential for the transporting of the compoimd in blood circulation and the delivery of resveratrol at the cell surface before cell membrane uptake. ... 

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