Toxicology drug interactions

Stansfeld, P.J., Sutcliffe, M.J. and Mitcheson, J.S. (2006) Molecular mechanisms for drug interactions with hERG that cause long QT syndrome. Expert Opinion on Drug Metabolism and Toxicology, 2, 81—94. 

Thummel, K.E. and Wilkinson, G.R. (1998) in vitro and in vivo drug interactions involving human CYP3A. Annual Review of Pharmacology and Toxicology, 38, 389-430. 

Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions a prospective based on conformational dynamics. Chemical Research in Toxicology, 14 (4), 338-347. 

At this point in the program, key information from other in vitro and in vivo studies become available, such as efficacy, pharmacokinetics, potential drug-drug interactions, metabolites and some early toxicology. All of these factors combined enable a first integrated risk assessment to be made. 

As discussed earlier, forensic pharmacology and toxicology are not limited to the study of drugs of abuse or poisons. These fields of science also have a growing role in the legal system to help resolve civil issues related to chemical exposure and cancer causation, medical malpractice as a result of drug interactions, and product liability issues. 

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. 

The first section deals with physicochemical properties of compounds, which could influence their pharmacokinetic behavior tremendously. In particular, solubility and lipophilicity impact the penetration across membranes resulting in different pharmacokinetics. The next sections are focused on the four big pillars of pharmacokinetics absorption, distribution, metabolism and excretion. Each of those is subdivided into specialized topics explaining more specific and more detailed aspects. Since many patients take some drugs simultaneously, drug-drug interactions is an important topic to be considered both under a pharmacokinetic and a toxicological point of view. 

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