Toxicology Bibliography

In a second generation of MEDLARS, which is planned for implementation this fall, it will be possible, with the aid of the data base established through the Chemical Abstracts registry system, to index biomedical publications with many more specific terms and chemicals than has been possible under MEDLARS I. While it is not projected that this extensive listing of chemical compounds be included in Index Medicus, it will be possible to provide such listings in other MEDLARS products. Thus a current publication of the Library, the Toxicology Bibliography, will list the biomedical literature by any desired chemical classification. 

Currently, there are many databases where the physicochemical, toxicological parameters required to perform a risk assessment can be obtained. It must be borne in mind that the existence of a quality control parameters included in the databases is of great importance. This quality control can be accomplished through periodic updating of the database, the inclusion of bibliographical references of the origin of each parameter, peer reviewed bibliography, etc. 

The Annual Plan also contains a bibliography of NTP publications from the previous year. A companion publication is the 1999 NTP Review of Current DHHS, DOE, and EPA Research Related to Toxicology. Similar to the Annual Plan, this document provides detailed summaries of both proposed and ongoing research. 

Therefore, the pharmacokinetic parameters, which can be derived from blood level measurements, are important aids to the interpretation of data from toxicological dose-response studies. The plasma level profile for a drug or other foreign compound is therefore a composite picture of the disposition of the compound, being the result of various dynamic processes. The processes of disposition can be considered in terms of "compartments." Thus, absorption of the foreign compound into the central compartment will be followed by distribution, possibly into one or more peripheral compartments, and removal from the central compartment by excretion and possibly metabolism (Fig. 3.23). A very simple situation might only consist of one, central compartment. Alternatively, there may be many compartments. For such multicompartmental analysis and more details of pharmacokinetics and toxicokinetics, see references in the section "Bibliography." The central compartment may be, but is not necessarily, identical with the blood. It is really the compartment with which the compound is in rapid equilibrium. The distribution to peripheral compartments is reversible, whereas the removal from the central compartment by metabolism and excretion is irreversible. 

The objective of the book has always been to form a sound introduction to the basic principles of the subject from a biochemical and mechanistic viewpoint. It is a testament to the vitality and progression of toxicology that the increasing sophistication, complexity, and expansion of the subject mean that revision of at least parts of this book is essential every few years. However, a book of this size cannot realistically cover all of the diverse aspects of toxicology in equal depth and detail and include all the new developments that are occurring, hence the extensive bibliography, which should be used to complement this text where more detail or other examples are wanted. 

Large abstracting facilities employ automated methods in the retrieval and transfer of information. A list of on-line computer systems containing bibliographies that include toxicology information is given in Table 9. 

Smith, F. A., compiler, Annotated Bibliography on the Pharmacology and Toxicology of... 

Comstock EG. 1980. Current literature on medical toxicology and a bibliography of vanadium. Clin Toxicol 16 541-548. 

John, J.E. Bibliography on the analysis and toxicology of heavy metals in tobacco and smoke Philip Morris, May 22, 1979, Bates Nos.1003579862, 1003579862/9867, 20A71. 

US National Library of Medicine Publications FTP to nlmpubs.nlm.nih.gov and login as nlmpubs for access to items such as NLM Current Bibliographies in Medicine, AIDS Bibliography, NLM Fact Sheets, chapters of the Online Services Reference Manual, Toxicology Information Program publications, and others in both ASCII and PostScript formats. 

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