Toxicants, origin

Acute Inhalation Toxicity (Original Guideline, adopted 12 May 1981)... 

Winograd, H.L. (1977). Acute croup in an older child. An unusual toxic origin. Clin. Pediatr. (Phila.) 16 884-7. 

If a mixture is diluted with a substance that has an equivalent or lower toxicity classification than the least toxic original ingredient, and which is not expected to affect the toxicity of other ingredients, then the new mixture may be classified as equivalent to the original mixture. Alternatively, the formula explained in paragraph 3.1.3.6.1 could be applied. 

Again, it could be just an accident. Plants evolved chemicals to kill predators, but a toxin that would kill an insect might just tantalize or sedate a human. The difference between a sedative and a poison is often a matter of dosage. The ingestion of toxins below lethal levels for the sake of euphoric effects has become known as intoxication, as a nod to its toxic origins. 

As the 1900s began, the bulk of chemically synthesized colors were derived from aniline, a petroleum product that in pure form is toxic. Originally, these were dubbed coal-tar colors because the starting materials were obtained from bituminous coal. Many of these colors are still used today, although with controls that ensure safe use. 

Stomatitis, other signs of irritation of the oropharynx, and a rash in and around the orifices have been described in patients taking tetracyclines. This may partly be considered as mucous membrane manifestations of allergic or toxic origin. Secondary infections by pathogenic organisms, such as C. albicans, viruses, or bacteria, should always be considered (88). 

Basically of a non-toxic origin (be aware of dioxin )—starting with relatively pure cellulose fibres and water. 

Immobilization by entrapment of P. laminosum When P. laminosum cells were entr ped in PU foams according to Brouers et al. (3), complete loss of viability was observed after 2-3 days of immobilization. Consequently, in an attempt to overcome the toxicity problems, different parameters were modified (temperature of polymerisation, prepolymer culture medium ratio, polymerisation time, light intensity, temperature of incubation, concentration of initial cell suspension, etc.) without any success. In all cases, high toxicity was observed which lead to a rapid death of the immobilized cells. It seems that this toxicity originates in the polymerisation reaction due to a possible release of toxic compounds and local increase of temperature and pressure. 

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