Tovomita

Geranyl-2,4,6-trihydrOxy-benzophenone (phenolic ketone) Tovomita krukovii (Clusiaceae) Candida albicans secreted aspartic protease (109 pM) [36]... 

Betulinic acid (lupane triterpene) Widespread Tovomita krukovii (Clusiaceae), Diospyros perigrina (Ebenaceae) Aminopeptidase N (7 pM) [68]... 

Genera Garcinia and Clusia have been reported as the main sources of PBDs but these compounds have been also isolated from other genera including Vismia, Tovomita, AUanblackia, Symphonia, Hypericum, Moronobea, Tovomiptosis and Ochrocarpus recently. 

About 100 PBDs have been isolated from different genera of the family Clusiaceae. Initially, these products were associated with genera Clusia and Garcinia, nowadays their distribution is associated with other 8 genera. Simple and complex structures have been isolated from genera Vismia, Symphonia, Hypericum, Tovomita, Allanblackia, Moronobea, Tovomiptosis and Ochrocarpus too. 

Three polyisoprenylated benzophenones closely related and named tovophenones A-C have been reported in Tovomita species. Spectral data of these compounds were consistent with a polyisoprenylated benzophenone with one m-hydroxyphenyl group and a lavandulyl chain (CioH17). Tovophenones A (19) and B (20) were isolated from the roots of... 

From Tovomita mangle G. Maritz (Guttiferae - sub-family Clusioideae) [1753]. 

Tovomita brasiliensis Trichophyton megnini Trichophyton rubrus Trichophyton violaceum Truncatella hartigii... 

Aspergillus caespitosus Ceratocystis Jimbriata Fusicoccum amygdali Hypoxy Ion spp. Semicarpus spp. Swartzia laevicarpa Tovomita brasiliensis Wood infected by fungi Synthesis... 

Tovophyllin B 272 was first isolated in 1972 from the wood of Tovomita macrophylla by de Oliveira et al. [119] and the structure was corrected in 1975 [120]. Tovophyllin B 272 is a significant inhibitor of Mycobacterium tuberculosis (MIC = 251g mP ) [121]. Therefore, as an important lead compound, the total synthesis of tovophyllin B 272 is... 

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