Candida albicans secretion

Candida albicans secreted aspartic protease Pepsin ... 

Ellagic acid (polyphenol) Widespread, ellagitannin product Fragaria spp. (Rosaceae) Candida albicans secreted aspartic protease (11 pM) Pepsin (37 pM) [35]... 

Geranyl-2,4,6-trihydrOxy-benzophenone (phenolic ketone) Tovomita krukovii (Clusiaceae) Candida albicans secreted aspartic protease (109 pM) [36]... 

White TC, Agabian N Candida albicans secreted aspartyl proteinases Isoenzyme pattern is determined by cell type, and levels are determined by environmental factors. J Bacteriol 1995 177 ... 

Chaffin, W. L. Lopez-Ribot, J. L. Casanova, M. Gozalbo, D. Martinez, J. P. Cell wall and secreted proteins of Candida albicans Identification, function, and expression. Microbiol. Mol. Biol. Rev. 1998, 62,130-180. 

A number of plant natural products have been isolated that inhibit an aspartic protease secreted by Candida albicans [35, 36], the most potent of which (IC50 values 8-14 pM) are the phenolics ellagic acid [35] and mattucinol-7-0-[4",6"-0-(5)-hexahydroxydiphenoyl]-P-glucopyranoside [35] and the triterpene betulinic acid [36] (Table 1). A macromolecule from Anchusa is a potent inhibitor of pepsin (K 20 nM) [37] (Table 1). 

Secreted Proteinases and Other Virulence Mechanisms of Candida albicans... 

White TC, Miyasaki SH, Agabian N Three distinct secreted aspartyl proteinases in Candida albicans. JBacteriol 1993 175 6126-6133. 

Monod M, Hube B, Hess D, Sanglard D Differential regulation of SAPS and SAP9 which encode two new members of the secreted aspartic proteinase family in Candida albicans. Microbiology 1998 144 2731-2737. 

Borg-von Zepelin M, Meyer I, Thomssen R, Wurzner R, Sanglard D, Telenti A, Monod M HIV-protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases. J Invest Dermatol 1999 13 747-751. 

Korting HC, Schaller M, Eder G, Hamm G, Bohmer U, Hube B Effects of the human immunodeficiency vims (HIV) proteinase inhibitors Saquinavir and Indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients. Antimicrob Agents Chemother 1999 43 2038-2042. 

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