Total joint arthroplasty

Joseph TN, Chen AL, Di Cesare PE. Use of antibiotic-impregnated cement in total joint arthroplasty. J Am Acad Orthop Surg 2003 11 38 7. 

Gonzalez Della Valle A, Khakharia S, Glueck CJ et al (2008) VKORC1 variant genotypes influence warfarin response in patients undergoing total joint arthroplasty a pilot study. Clin Orthop Relat Res 467 1773-1780... 

O K. MURATOGLU, D.O.O CONNOR, C.R. BRAGDON, J. DELANEY, M. JASTY, W.H. HARIS, E. MERRILL, P. VENUGOPALAN, Gradient crosslinking of UHMWPE using irradiation in molten state for total joint arthroplasty , Biomaterials, 23 (2002)717-724... 

F. (2014) Ceramic bearings in total joint arthroplasty. Drugs Dis. Proced. www.emedicine.medscape.com/article/ 13S8242 (accessed 13 November 2014). 

Lewis CG and Sunderman FW JR (1996) Metal carcinogenesis in total joint arthroplasty. Clin Orthop 3295 264-268. 

S McCue, E Berg, E Saunders. Efficacy of double-gloving as a barrier to microbial contamination during total joint arthroplasty. J Bone Joint Surg 63-A(5) 811-813, 1981. 

Surface-modified polyolefin materials are widely used in biomedical field. Low-temperature plasma-treated PE was well suited for biomedical application. UHMWPE after surface modification with low-temperature plasma is the principal material used to replace damaged cartilage in total joint arthroplasty or the surgical reconstmction of a diseased joint [73]. The UHMWPE having desirable mechanical properties and biocompatibility is used in orthopaedic implants and joint socket in bone replacement. 

Kurtz S.M., O.K. Muratoglu, M. Evans, A.A. Edidin. 1999. Advances in the processing, sterilization, and crossUnking of ultra-high molecular weight polyethylene for total joint arthroplasty Biomaterials 20 1659-1688. 

Mabrey J.D., A. Afsar-Keshmiri, G.A. Engh, et al. 2002. Standardized analysis of UHMWPE wear particles from failed total joint arthroplasties. J Biomed Mater Res 63 475M83. 

Kurtz S.M., C.W. Jewett, J.R. Foulds, and A.A. Edidin. 1999. Miniature specimen mechanical testing technique scaled to articulating surface of polyethylene components for total joint arthroplasty. J Biomed Mater Res 48(1) 75-81. 

Mazzucco D. Spector M. The John Charnley Award Paper the role of joint fluid in the tribolo of total joint arthroplasty. Clinical Orthopaedics and Related Research 2004 429 17-32. 

The developments of innovative bearing surfaces made of UHMWPE with optimized crosslink densities may provide improved in-vivo wear resistance and long-term structural stability. Such improvements are essential in avoiding peri-prosthetic osteolysis, the leading cause of implant failure, and may ultimately extend the life of total joint replacements. Such material improvements have the potential to make important contributions to the field of total joint arthroplasty. 

In cemented total joint arthroplasties, acrylic bone cement functions as the piima ry load bearing material used to transfer loads from the implant to the bone. Bone cement Is formed from an exothermic reaction of benzoyl peroxide initiator present In polymethylmethacrylate powder (PMMA) and AI,AI-dimethyl-p-tolui-dene In methylmethacrylate monomer liquid (MMA), resulting in polymerization of PMMA to form a solid cement matrix. The in vivo integrity and performance of bone cement Is necessary for longevity of orthopedic implants, because it is believed that mechanical failure of the bone cement layer can lead to aseptic loosening of the Implant [101]. 

Total joint arthroplasty has become the operation of choice in most cases of hip and knee problems [44], it remains the most effective and common treatment for eradication of infection, showing an infection control rate between 80% and 95% [16,45,46]. 

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