Torreyal synthesis

Radiofrequency-based parallel synthesis tools are commercialized by IRORI Quantum Microchemistry, 11025 North Torrey Pines Road, La Jolla, CA 92037, USA. 

Calcium oxalate results from the reaction of oxalic acid and calcium ions (McNair, 1932), and oxalic acid itself is an effective deterrent to herbivores in its own right (Amott and Webb., 1983). At least four different biochemical pathways have been shown to result in the synthesis of oxalate in plants (Raven et al., 1982). Utilizing radiocarbon-labeled ascorbic acid administered to roots of Yucca torreyi L. (Torrey s yucca) the incorporation into vacuole crystal bundles demonstrated that ascorbate is an important precursor to oxalate in this plant (Horner et ai, 2000). 

In a continuation of their studies on the Claisen-Cope rearrangement, Thomas etal have utilised this procedure in the synthesis of torreyaland dendro-lasin. Thus, pyrolysis of the ether (20), derived from the reaction of 3-furyl-methanol with l-ethoxy-2-methylbuta-1,3-diene, gave the aldehyde (21). This, on reduction to the corresponding alcohol and further treatment with the above diene, yielded torreyal (22, R = CHO) which could be converted to dendrolasin... 

Carbohydrate Synthesis and Protein Expression Core Resource, Consortium for Functional Glycomics, The Sciipps Research Institute, Department of Molecular Biology CB216,10550 North Torrey Pines Road,... 

Radiofrequence-based parallel synthesis tools are commercialized by IRORl Quantum Microchemistry, 11025 North Torrey Pines Road, La Jolla, CA 92037, USA. K Burgess, AI Liaw, N Wang. Combinatorial technologies involving reiterative division/coupling/recombination statistical considerations. J Med Chem 37 2985-2987, 1994. 

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