Topoisomerases interactions

Fig. 5. Structures of topoisomerase interactive drugs given in Table 4.

Topoisomerase Interactive Drugs. Topoisomerases I and II have emerged as interesting targets for the design of new anticancer agents (Table 4),... 

Clinical Development of Topoisomerase-Interactive Drugs Franco M. Muggia and Howard A. Burris... 

Takimoto CH. Topoisomerase interactive agents. In DeVita VT Jr, Heilman S, Rosenberg SA, eds. Cancer Principles and Practice of Oncology. 7th Ed. Baltimore Lippincott Williams Wilkins, 2005 375-390. 

Hoet S, Stevigny C, Block S, et al. Alkaloids from Cassytha filiformis and related apor-phines anti-trypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases. Planta Med 2004 70 407-413. 

Interestingly, nucleolin interacts with several key DNA repair and recombination proteins. First of ah, it interacts with topoisomerase I through its N terminus (Bharti et al, 1996 Edwards et al, 2000). This interaction does not modify the enzymatic activity of topoisomerase I per se, but it could play important role in its predominantly nucleolar localization as it was demonstrated in yeast (Edwards... 

Haq 1 (2002) Thermodynamics of drug-DNA interactions. Arch Biochem Biophys 403 1-15 Hsiang YH, Hertzberg R, Hecht S, Liu LE (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase 1. J Biol Chem 260(27) 14873—14878 Hurley LH (2002) DNA and its associated processes as targets for cancer therapy. Nat Rev cancer 2 188-200... 

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