Topoisomerase anthracycline interactions with

The anthracyclines are aminoglycosidic derivatives of tetracyclic compounds that contain an anthraquinone chromophore. Originally, dauno-mycin and adriamycin, its hydroxy analogue, were isolated from cultures of Streptomyces peucetiusd The main target of these drugs appears to be DNA, most likely by formation of an intercalation complex. The drugs also affect topoisomerase II, an enzyme which interacts with the DNA that has been modified by intercalation. ... 

Anthracyclines, like daunomycin and doxorubicin, are known to interact with nucleic acids, particularly with DNA, as well as with a variety of proteins, including albumins, ABC cassette transporters like Pgp, cytochromes, topoisomerases, and other enzymes. Focus on the anthracycline-DNA interactions in current research stems from recognition of the role of DNA... 

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