Topoisomerase doxorubicin interaction with

Anthracyclines, like daunomycin and doxorubicin, are known to interact with nucleic acids, particularly with DNA, as well as with a variety of proteins, including albumins, ABC cassette transporters like Pgp, cytochromes, topoisomerases, and other enzymes. Focus on the anthracycline-DNA interactions in current research stems from recognition of the role of DNA... 

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