Toluene monooxygenase hydroxylase

Sazinsky MH, Bard J, Di Donato A, Lippard SJ. 2004. Crystal structure of the toluene/o-xylene monooxygenase hydroxylase from Pseudomonas stutzeri 0X1 insight into the substrate specificity, substrate channeling, and active site tuning of multicomponent monooxygenases. JBiol Chem 279 30600-30610. 

McCormick MS, Sazinsky MH, Condon KL, Lippard SJ. 2006. X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior. J Am Chem Soc 128 15108-15110. 

Murray LJ, Garcia-Serres R, Naik S, Huynh BH, Lippard SJ. 2006. Dioxygen activation at non-heme diiron centers characterization of intermediates in a mutant form of toluene/o-xylene monooxygenase hydroxylase. JAm Chem Soc 128 7458-7459. 

Sazinsky, M.H., Bard, J., Di Donato, A., Lippard, S.L. 2004. Crystal Structure of the toluene/o-xy-lene monooxygenase hydroxylase from Pseudomonas stutzeri 0X1 J. Biol Chem. 279 30600-30610. 

Hydrocarbon hydroxylases introducing oxygen into nonoxygenated rings Toluene, phenanthrene, pyrene monooxygenases Hydrocarbon epoxidases... 

The alkane hydroxylase belongs to a family of nonheme iron oxygenases. There is some structural similarity between the nucleotide sequence of the integral-membrane alkane hydroxylase and the subunits of the monooxygenase encoded by xylA and xylM in the TOL plasmid that are involved in hydrox-ylation of the methyl groups in toluene and xylene in Pseudomonas putida PaWl (Suzuki et al. 1991). 

SALICYLATE 1-MONOOXYGENASE SARCOSINE OXIDASE STEROID HYDROXYLASES SULFITE OXIDASE SULEUR DIOXYGENASE THYMIDINE 2 -HYDROXYLASE TOLUENE DIOXYGENASE XANTHINE OXIDASE... 

Mitchell KH, Studts JM, Fox BG. 2002. Combined participation of hydroxylase active site residues and effector protein binding in a para to ortho modulation of toluene 4-monooxygenase regiospecificity. Biochemistry 41 3176-3188. 

Rudd DJ, Sazinsky MH, Lippard SJ, Hedman B, Hodgson KO. 2005. X-ray, absorption spectroscopic study of the reduced hydroxylases of methane monooxygenase and toluene/o-xylene monooxygenase differences in active site structure and effects of the coupling proteins MMOB and ToMOD. Inorg Chem 44 4546-4554. 

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