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Tissue-nonspecific alkaline phosphatase TNAP

A physiologic phosphate concentration is required for bone mineralization. Lowering the concentration prevents mineralization, but raising it does not ensure precipitation because pyrophosphate is present to inhibit precipitation. The concentration of PPi in cartilage and bone is controlled by three enzymes, two on the outer surface of matrix vesicles (Fig. 9.5b). One is tissue-nonspecific alkaline phosphatase (TNAP), which decreases stromal pyrophosphate and the other is NTP-PPi hydrolase (also called plasma cell membrane glycoprotein-1), which increases it. The progressive ankylosis gene product (ANK protein) is expressed by osteoblasts to add to the pyrophosphate of the osteoid matrix from osteoblast cytosol. [Pg.140]

Mineralization therefore occurs in bone because of the exclusive co-expression in osteoblasts of type I collagen and tissue-nonspecific alkaline phosphatase (TNAP). The abnormal appearance of TNAP in any cell that also produces fibrillar collagen (ectopic TNAP expression) gives rise to pathological (nonbacterial) mineralization, which is outside the scope of this text. [Pg.140]

Dahl R, Sergienko EA, Su Y et al (2009) Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem 52 6919-6925... [Pg.50]

Robotic Implementation of Assays Tissue-Nonspecific Alkaline Phosphatase (TNAP) Case Study... [Pg.53]

Key words High-throughput screens, HTS, Chemical libraries. Laboratory automation. Automated assays. Robotics, Phosphatase assays. Assay development. Implementation, Enzymes, Alkaline phosphatases. Tissue-nonspecific alkaline phosphatase (TNAP)... [Pg.53]

It has been hypothesized that phosphate accelerates this chondro-osteogenic conversion by inducing expression of runt-related transcription factor 2 (RUNX2), osteocalcin and tissue-nonspecific alkaline phosphatase (TNAP) [2]. Elevated TNAP further favors vascular calcification by hydrolyzing the calcification inhibitor inorganic pyrophosphate (PPi) [3-6]. In the Enppl mouse model of GACI, inhibition of TNAP can restore PPj to sufficient levels to maintain normal mineralization [3]. [Pg.125]

Alkaline phosphatase (AP orthophosphoric monoester phospho-hydrolase, EC 3.1.3.1) isozymes are present in a wide range of species from bacteria to man and are capable of dephosphorylation and transphosphorylation of a broad spectrum of substrates in vitro [1]. Their broad snbstrate specificity and localization on the outside leaf of the cytoplasmic membrane suggests potential involvement in numerons extracellular processes. In humans, four isozymes of APs have been identified. One of them, tissue-nonspecific alkaline phosphatase (TNAP), is ubiquitously expressed, demonstrating especially high level of expression in bone, liver and kidney tissues. Three other isozymes demonstrate tissue-specific... [Pg.135]

See other pages where Tissue-nonspecific alkaline phosphatase TNAP is mentioned: [Pg.6]    [Pg.8]    [Pg.27]    [Pg.28]    [Pg.55]    [Pg.85]    [Pg.103]    [Pg.103]    [Pg.116]    [Pg.135]    [Pg.146]    [Pg.322]   
See also in sourсe #XX -- [ Pg.6 , Pg.8 , Pg.20 , Pg.21 , Pg.28 , Pg.29 , Pg.30 , Pg.31 , Pg.32 , Pg.33 , Pg.34 , Pg.35 , Pg.36 , Pg.37 , Pg.38 , Pg.39 , Pg.40 , Pg.41 , Pg.44 , Pg.45 , Pg.85 , Pg.86 , Pg.87 , Pg.88 , Pg.89 , Pg.90 , Pg.91 , Pg.92 , Pg.93 , Pg.94 , Pg.95 , Pg.96 , Pg.97 , Pg.98 , Pg.99 , Pg.103 , Pg.104 , Pg.105 , Pg.106 , Pg.107 , Pg.108 , Pg.109 , Pg.110 , Pg.111 , Pg.116 , Pg.117 , Pg.118 , Pg.119 , Pg.120 , Pg.121 ]



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Alkaline phosphatase

Alkaline phosphatase nonspecific

Nonspecificity

TNAP

Tissue-nonspecific alkaline phosphatase

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