Vascular calcification

Spronk HM (2006) Vitamin K epoxide reductase complex and vascular calcification is this the important link between vitamin K and the arterial vessel wall Circulation 113 1550-1552... [Pg.1301]

Calciphylaxis is a rare, often fatal disease, characterized clinically by progressive cutaneous necrosis and ulceration and histologically by vascular calcification and thrombosis. It has been described in association with end-stage renal disease and hyperparathyroidism. [Pg.1039]

It has been known for more than 100 years that patients with kidney failure have vascular calcification. In 1855, Virchow noted that vascular calcification is an ossification, and not a mere calciiication. Serial x-ray studies and ultrasound imaging of large arteries confirm increased calcification in patients on dialysis over many years.Studies from France have linked the presence of vascular calcification with reduced survival on dialysis. ... [Pg.1725]

Goldsmith DJ, Covic A, Sambrook PA, Ackrill P. Vascular calcification in long-term hemodialysis patients in a single unit a retrospective analysis. Nephron 1997 77 37-43. [Pg.1732]

Guerin AP, London GM, Marchais SJ, Metivier F. Arterial stiffening and vascular calcifications in end-stage renal disease. Neplirol Dial Transplant 2000 15 1014-21. [Pg.1733]

Shanahan CM, Proudfoot D, Earzaneh Far A, Weissberg PL. The role of Gla proteins in vascular calcification. Crit Rev Eukaryot Gene Expr 1998 8 357-75. [Pg.1741]

Abedin M, Tintut Y, Demer LL (2004) Vascular calcification mechanisms and clinical ramifications. Arte-rioscler Thromb Vase Biol 24 1161-1170... [Pg.116]

Chertow GM. Slowing the progression of vascular calcification in hemodialysis. J Am Soc Nephrol 2003 14(Suppl 4) S310-S314. [Pg.849]

Lomashvili KA, Garg P, Narisawa S et al (2008) Upregulation of alkaline phosphatase and pyrophosphate hydrolysis potential mechanism for luremic vascular calcification. Kidney Int 73 1024-1030... [Pg.25]

Key words TNAP, LAP, Mineralization, Epilepsy, Vascular calcification, LPS, Inflammation,... [Pg.27]

Paradoxically, whereas aging is associated with a decrease in bone formation [121], it is also linked to vascular calcification [122]. Vascular calcification can form by intramembranous ossification or by endochondral bone formation, and eventually lead to the appearance of mature bone, with bone marrow, in the vasculature... [Pg.40]

Lencel P, Hardouin P, Magne D (2010) Do cytokines induce vascular calcification by the mere stimulation of TNAP activity Med Hypotheses 75 517-521... [Pg.50]

Ishimura E, Okuno S, Kitatani K et al (2002) Different risk factors for peripheral vascular calcification between diabetic and non-diabetic haemodialysis patients-importance of glycae-mic control. Diabetologja 45 1446-1448... [Pg.50]

Medial localization of mineralizationregulating proteins in association with Monckeberg s sclerosis evidence for smooth muscle cell-mediated vascular calcification. Circulation 100 2168-2176... [Pg.50]

Tintut Y, Patel J, Territo M et al (2002) Monocyte/macrophage regulation of vascular calcification in vitro. Circulation 105 650-655... [Pg.50]

Here, we describe methods to evaluate the ability of small molecules inhibitors of TNAP and PHOSPHOl in preventing mineralization of primary cultures of murine vascular smooth muscle cells. The procedures are also applicable to primary cultures of calvarial osteoblasts. These cell-based assays are used to complement kinetic testing during structure-activity relationship studies armed at improving scaffolds in the generation of pharmaceuticals for the treatment for medial vascular calcification. [Pg.125]

It has been hypothesized that phosphate accelerates this chondro-osteogenic conversion by inducing expression of runt-related transcription factor 2 (RUNX2), osteocalcin and tissue-nonspecific alkaline phosphatase (TNAP) [2]. Elevated TNAP further favors vascular calcification by hydrolyzing the calcification inhibitor inorganic pyrophosphate (PPi) [3-6]. In the Enppl mouse model of GACI, inhibition of TNAP can restore PPj to sufficient levels to maintain normal mineralization [3]. [Pg.125]

Towler DA (2008) Vascular calcification a perspective on an imminent disease epidemic. IBMS Bonekey 5 41-58... [Pg.133]

O Neill WC, Sigrist MK, McIntyre CW (2010) Plasma pyrophosphate and vascular calcification in chronic kidney disease. Nephrol Dial Transplant 25 187-191... [Pg.133]

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