Tissue interaction analysis materials

Part II of this book represents the bulk of the material on the analysis and modeling of biochemical systems. Concepts covered include biochemical reaction kinetics and kinetics of enzyme-mediated reactions simulation and analysis of biochemical systems including non-equilibrium open systems, metabolic networks, and phosphorylation cascades transport processes including membrane transport and electrophysiological systems. Part III covers the specialized topics of spatially distributed transport modeling and blood-tissue solute exchange, constraint-based analysis of large-scale biochemical networks, protein-protein interactions, and stochastic systems. 

In most of the early work on cell wall analysis, the alcohol insoluble residue (AIR), or the alcohol-benzene extractive free residue, was used as the starting material. Such residues may be suitable for tissues relatively poor in intracellular proteins, polyphenols, and starch, such as grasses and certain fruits and vegetables. Even with these products, interactions between the cell wall polymers occur, due to the dehydration effects of alcohol, resulting in the formation of artifacts. However, for starch- and protein-rich products additional complications arise because of coprecipitation effects. In oats and potatoes, for example, the starch to... 

The surface of any material governs its interactions with the environment. Knowledge over and control of these interaction is especially important when a material is in contact with the biosystem, for example, when applied as transplant, in tissue engineering, in cell cultures, and in blood contact, as weU as in biosensors in medicinal diagnosis, fluids analysis, environmental moititoring, and many other areas. Whereas, on the one hand, the bulk properties of the material are essential for its successful application, for example, as a catheter or a heart valve, special attention has to be paid to render to the surface suitable biocompatible or bioactive properties, no matter of the chemical composition of the bulk material. This is usually achieved by any surface modification process by low molar mass or polymeric compounds. An essential feature of such a modification procedure is the need for a permanent and bioresistant surface finish [87]. 

---