Tissue In Growth

Fig. 25.2 Survival of a split-thickness skin graft applied over Permacol paste. SSG day 0, assessed 6 days post grafting, haematoxylin and eosin, xlOO. Epithelium of a split-thickness skin graft (SSG) was viable and well-structured. Dermal component of the graft was intimately attached to the well-cellularised Permacol paste PP) with minimal signs of the inflammatory reaction. Dermal substitute biomaterial integrated into the full-thickness wound via granulation tissue in growth present at the paste and wound bed (WB) interface...

The fabrics used in these devices also differ. Polyester is a commonly used polymer in medical applications. This polymer is used in the ASO, the BCSO, the CS/SF and the DAW devices. The GHSO device, on the other hand, is composed of ePTFE. Both of these polymers are known to be reasonably inert, flexible, durable and resistant to degradation. Additionally, their creep resistance is acceptable and they are therefore used in vascular applications where the fabric s creep behavior is an important consideration. The fabric construction of the ASO device is unknown, but it appears to be a nonwoven. This specific construction provides a mesh, in which pore sizes can easily be controlled. This is of importance when considering tissue in-growth. Additionally, if the fabric is made with very small pores, it... 

The suitable material properties of PHB such as compatibility, support cell growth, guide and organize cells allow tissue in growth. 

Incorporation of microchannels/tubes into a construct that facilitates transport of oxygen and nutrients as well as supports neovascularization and host tissue in growth [123]. 

This team of investigators reported on the resorption process of PLGA/HAp nanocomposites implanted into rabbit submaxilla bones [157]. The resorption of composite occurred simultaneously with the formation of new bone tissue. The authors found that 3 weeks after implantation, the bone-implant interface becomes rough and polymer losses can be observed, with bone tissue in-growth. SEM microphotographs taken 12 weeks after implantation indicate the presence of fractal apatite grains growing towards the voids left after the resorbed polymer the voids were completely filled by bone tissue a year after implantation. 

The extraordinary properties of the biopolymers are due to their excellent biocompatibility and biodegradability. Synthetic polymers are also attractive because they can be fabricated into various shapes with desired pore morphologic features conducive to tissue in-growth. Furthermore, the polymers can be designed with chemical functional groups that can induce tissue in-growth [402]. Polysaccharides have a surprising ability for stracture formation by supramolecular interactions, and, because of this ability, they can be used to modify advanced materials. 

Biodegradable synthetic polymers offer a number of advantages over other materials because of the possibility to tailor mechanical properties and degradation kinetics, and because they can be fabricated into various shapes with desired pore morphologic features conducive to tissue in-growth. 

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