Tissue engineering scaffold fabrication techniques

Electrospinning technique has proved to be efficient in nanofibers production for diverse applications such as biomedical applications, liquid crystal devices, nanofiltration, etc. However, it has been very promising technique for tissue engineered scaffolds fabrication. This reiterates the fact that through this technique, it is possible to fabricate scaffolds by resembling the namral ECM inside human body. The features of electrospun nanofibers can be manipulated so that (i) the dimensions of nanofibers could resemble the namral tissue fibers dimensions in the body and (ii) the scaffolds porosity could be manipulated to mimic that of the namral tissues inside the body. High porosity is mandatory in scaffolds for better fluid perfusion and cell proliferation. 

There is currently a renewed interest in the use of electrospinning techniques for the fabrication of membranes. Chapter 8 reviews the use of this versatile technique for the production of nanofiber webs or membranes. The chemical and physical properties of nanofiber manbrane surfaces play an important role in their application to filtration, biomedical materials, tissue engineering scaffolds, drug delivery... 

This chapter provides an overview of biodegradable tissue-engineered scaffolds that are here grouped according to the fabrication technique required for their... 

The following sections describe the processing techniques used for the fabrication of tissue-engineered scaffolds. Within each section, a table provides a comparison... 

McHugh, K.J., Tao, S.L., Saint-Geniez, M. A novel porous scaffold fabrication technique for epithelial and endothelial tissue engineering. J. Mater. Sci. Mater. Med. 24, 1659-1670 (2013). doi 10.1007/sl0856-013-4934-l... 

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