Tissue engineering peripheral nerve

Leach JB (2006) Tissue-engineered peripheral nerve. In Akay M (ed) Wiley encyclopedia of biomedical engineering. Wiley, Hoboken, NJ... 

In biomedical applications, transglutaminases have been used for tissue engineering materials such as enzymatically crosslinked collagen [60-63] or gelatin scaffolds [64-69]. Even melt-extruded guides based on enzymatically crosslinked macromolecules for peripheral nerve repair have been reported [70]. 

Midha R, Shoichet MS, Dalton PD et al (2001) Tissue engineered alternatives to nerve transplantation for repair of peripheral nervous system injuries. Transplant Proc 33 612... 

Mosahebi, A., Wiberg, M., Terenghi, G. Addition of fibronectin to alginate matrix improves peripheral nerve regeneration in tissue-engineered conduits. Tissue Engineering. 2003, 9, 209-218. 

V. Mukhatyar, L. Karumbaiah, J. Yeh, R. Bellamkonda, Tissue engineering strategies designed to realize the endogenous regenerative potential of peripheral nerves, Adv. Mater. 21 (2(X)9) 4670-4679. 

Various electrospun nanofibers made of PCL, PCL/hydroxyapatite, polystyrene, and SF were surface-modified by air or argon plasma, resulting in an improved cell adhesion and proliferation (Venugopal et al. 2008 Prabhakaran et al. 2008 Yang et al. 2008). PCL nanofibrous scaffolds were surface-modified by a simple plasma treatment process to enhance the Schwann cell adhesion, proliferation, and interactions with the nanofibers necessary for nerve tissue formation (Prabhakaran et al. 2008). The results showed that plasma-treated PCL nanofibrous scaffolds are a cost-effective material compared with PCL/collagen scaffolds and can potentially serve as an ideal tissue-engineered scaffold, especially for peripheral nerve regeneration. 

Gao, X., Wang, Y., Chen, J., Peng, J., 2013. The role of peripheral nerve ECM components in the tissue engineering nerve construction. Rev. Neurosci. 24,443-453. 

K., Diao, E., Bao, X, et al (2011) Engineering bi-layer nanofibrous conduits for peripheral nerve regeneration. Tissue Eng. Part C Methods, 17 (7), 705-715,... 

In contrast, spider silk is devoid of sericin and hence does not evoke the same biological or immunological reactions. Thus, spider silk has better biocompatibility and is a preferred biomaterial for suture applications. It has also been studied as a material for regenerative nerve conduits to promote peripheral nerve regeneration [33]. Silk s unique mechanical properties coupled with its ability to be fabricated into different textile structures enable its use in tissue engineering scaffolds that mimic the mechanical properties of native tissues. For example, silk filaments have been converted into a braided rope stracture that acts as a scaffold for the regeneration of anterior cruciate ligaments (ACL) [34]. 

Yu, X. and Bellamkonda, R.V., Tissue-engineered scaffolds are effective alternatives to autografts for bridging peripheral nerve gaps. Tissue Eng., 9,421,2003. 

Hadlock, T., EHsseeff, J., Langer, R., Vacanti, J., and Cheney, M., A tissue-engineered conduit for peripheral nerve repair. Arch. Otolaryngol. Head Neck Surg. 124,1081-1086,1998. 

Fansa, H, Keilhoff, G, Wolf, G, and Schneider, W. 2001. Tissue engineering of peripheral nerves A comparison of venous and acellular muscle grafts with cultured Schwann cells Blast Reconstr Surg 107(2) 485-494. 

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