Tissue-adhesive surfaces, biocompatibility

The material must allow a surface treatment that ensures a good adhesion of biocompatible ceramic coatings or living tissues. 

Thin block copolymer films on surfaces are interesting materials for biomedical and/or biotechnological applications, e.g. tissue engineering. Their chemical versatility allows for the adjustment of desired properties, such as protein repellence or adhesion, and biocompatibility. Mostly, biodegradable PLA- or PCL-based block... 

Hydrophobicity of biomedical polymers influences the biocompatibility depending on the particular application such as tissue engineering, blood contacting devices, and dental implants [35]. Polymers are dynamic structures and can switch their surface functional groups depending on the environment. For example, polymeric biomaterials need to have a hydrophilic smface for most of the applications, so that the cell-adhesive proteins present in the serum will be adsorb and promote cell adhesion and proliferation. This is achieved by snrface treatment procedures such as... 

Cell adhesion to artificial surfaces plays a key role in a wide variety of demanding products and technologies such as medical implants or bioreactor systems. Adhesion of eukaryotic and bacterial cells to a biomaterial surface can be a major factor mediating its biocompatibility. For a proper integration of an implant into tissue, cell adhesion may be desired, whereas bacterial cell adhesion to medical devices must be prevented in order to minimize the risk of infections and toxicity. 

In a design approach unique among gecko-inspired adhesives, hiodegradable dextran-coated poly(glycerol-co-sebacate acrylate) has been used to create patterned arrays of microscale truncated cones, and used to improve attachment of adhesive tapes to tissue surfaces. While this biocompatible, elastomeric material is not intended for reversible adhesion and... 

---