Time-sharing mode

The computer program for drawing these plots is tied to a modified teletype ASR 33 which has had Selsyn motors and electronics attached to turn it into a point plotter. The unit was sold by the Typagraph Corp. and is their model T-3. This works in a time-sharing mode with a commercial time-sharing computer company (Dialcom, Inc., Silver Spring, MD.). 

A recently introduced method called SWIFT (SWeep Imaging with Fourier Transform) is a fundamentally different approach to MRI which is particularly well suited to imaging objects with extremely fast spin-spin relaxation rates." The method exploits a frequency-swept excitation pulse and virtually simultaneous signal acquisition in a time-shared mode. The experimental steps needed to properly implement HSn pulses in SWIFT and compact expressions are presented to estimate the amplitude and flip angle of the HSn pulses, as well as the relative energy deposited by the SWIFT sequence. 

In the off-line mode of use of the drug file the data-base, stored In a time-shared computer. Is Interrogated through a remote device such as a cathode ray terminal The questions that may be asked Include all the affects of a drug, all the drugs that affect a test, or more specifically does a particular drug affect a particular test procedure by a particular mechanism ... 

Figure 4.12. Power modes and their time-shares for reversible fuel cell (RFC) plus solar cell system proposed as a power source for a stratospheric airship. (From K. Eguchi, T. Fujihara, N. Shinozaki, S. Oka-ya (2004). Current work on solar RFC technology for SPF airship. In Proc. 15 World Hydrogen Energy Conf., Yokohama. 30A-07, CD Rom. Copyright attributed to the Hydrogen Energy Soc. Japan.)...

Based on analysis of electronic crystallography and NMR data for the bindings of Taxol and epothilone A to tubulin subunits, it was proposed that they did not share a common pharmacophore (similar binding mode and sites) as hypothesized for a long time, because they bind to their receptors uniquely and independently. Also, the T-shape conformation of Taxol binding to tubulin was supported from this study. 

Figure 3. Contour plot of an LC/MS of a chymotryptic digest of modifled phosphorylase b, printed in black and white mode. Circles indicate the positions of peaks from a contour plot of the le-acetylated digest for comparison. The two significant shared peaks (indicated by arrows) are the N-terminal blocked peptide (at m/z=514 and 13 min elution time) and the leucine enkephalin internal standard (at m/z=SS6 and 21 min elution time).

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