Tiabendazole

QHgN2 95-54-5) see Benperidol Droperidol Mibefradil hydrochloride Pyrazinamide Tiabendazole Tibezonium iodide... 

C4H3NO2S 397S-08-8) see Tiabendazole (/ )-4-thiazoIidinecarboxylic acid (C4H,N02S J4592-47-7) see Telmesteine 2,4-thiazolidinedione... 

Instances of both hypoglycemia and hyperglycemia have been recorded in patients taking tiabendazole. 

Cutaneous Up vs inigr ftns Arfry/osJemo tiabendazole topical for Calamine lotion for symptom relief... 

Tiabendazole (formerly known as thiabendazole) inhibits cellular enzymes of susceptible helminths. Gastrointestinal, neurological and hypersensitivity reactions, liver damage and crystalluria may be induced. 

Tiabendazole is a non-carbamate benzimidazole which inhibits cellular enzyme systems specific to some species of helminths. It is active against Giardia lamblia, but less effective than albendazole and mebendazole. It was at... 

Common toxic effects of tiabendazole include nausea, vomiting, and dizziness. Malaise and drowsiness are also common. Liver disorders can occur and are the most serious complications. Most systems can on occasion be affected. Allergic reactions are essentially due to parasite destruction rather than a direct effect of the drug itself. Chills, fever, lymphadenopathy, angioedema, and pruritic rashes all can occur and treatment should in that case be stopped, since otherwise more serious reactions (for example Stevens-Johnson syndrome) can follow. Tumor-inducing effects have not been reported. 

Bradycardia, hypotension, and syncope can occur with tiabendazole, even to the point of collapse (1). 

Somnolence has been described with high doses of tiabendazole rectally or orally, and drowsiness, headache, malaise, and fatigue are common (1). Patients should be warned not to drive or carry out other potentially hazardous pursuits during treatment. 

Effects of tiabendazole on vision are not uncommon abnormal sensations in the eyes, xanthopsia (a yellow tinge to objects), blurred vision, drying of mucous membranes, and sicca syndrome all have been described (4). 

Allergic reactions to tiabendazole can cause keratoconjunctivitis sicca as part of Sjogren s syndrome (5). Tinnitus has been attributed to tiabendazole (6). 

Nausea, anorexia, vomiting, abdominal pain, and diarrhea are common and occur in a high proportion of patients taking tiabendazole (8). 

Parenchjmal hver damage can occur in patients taking tiabendazole and abnormal liver function tests have been documented (9). There have been well-studied cases of bile duct injury, which can lead to micronodular cirrhosis (10), and a case in which these various forms of liver disorder co-existed and hver transplantation proved necessary (11). 

In view of these and previous cases of severe cholestasis after tiabendazole and the availability of less toxic equally effective drugs (albendazole or preferably ivermectin), tiabendazole must be considered obsolete in the treatment of strongyloidiasis. 

Crystalluria has been noted in patients taking tiabendazole, sometimes with hematuria (1). 

Tiabendazole can give the urine an asparagus-like smell because of the presence of a mercaptan metabolite of tiabendazole (14). 

Very occasionally a topical form of tiabendazole is used, for example to treat rosacea, and in one such case contact dermatitis aggravated by sunlight occurred as a complication, with positive tests for tiabendazole sensitivity (17). 

Tiabendazole can cause severe muscle pain on exercise (18). 

Tiabendazole is metabolized almost completely by the liver, and its active metabolites are substantially excreted by the kidney the risk of toxicity may therefore be greater in patients with impaired renal function (20). 

Tiabendazole can markedly increase serum concentrations of theophylline, with a prolonged half-hfe and a reduced clearance rate concomitant administration of theophylline and thiabendazole resulted in severe nausea and vomiting (21). 

Eland lA, Kerkhof SC, Overbosch D, Wismans PJ, Strieker BH. Cholestatische hepatitis toegeschreven aan her gebruik van tiabendazole. [Cholestatic hepatitis ascribed to the use of thiabendazole.] Ned Tijdschr Geneeskd 1998 142(23) 1331. ... 

Albendazole, ag interferon, anti-CD5 antibody, azathioprine, dimercaprol, hycanthone, interferon, interleukin 2, iron dextran, ivermectin, ketoconazole, lansoprazole, metoprolol, nalidixic acid, OKT3, pefloxacin, tiabendazole, zidovudine... 

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