Tiabendazole Theophylline

Tiabendazole can markedly increase serum concentrations of theophylline, with a prolonged half-hfe and a reduced clearance rate concomitant administration of theophylline and thiabendazole resulted in severe nausea and vomiting (21). 

Theophylline - bronchodilator asthma, chronic bronchitis Thipental - intravenous general anaesthetic Tiabendazole - anthelmintic Tioconazole - antifungal... 

Tiabendazole is known to have elinieally significant inhibitory effects on the metabolism of theophylline , (p.ll71), and therefore would also be expected to affect caffeine metabolism. There is too little information to suggest that patients taking tiabendazole should avoid caffeine-containing... 

A retrospective study of patients given theophylline and tiabendazole found that 9 out of40 (23%) had developed elevated serum theophylline levels and of those 9 patients, 5 experienced significant toxicity, with 3 rc-... 

Uncertain. It is suggested that tiabendazole inhibits the metabolism of theophylline, probably by the cytochrome P450 isoenzyme CYP1A2 in the liver, thereby prolonging its stay in the body and raising its serum levels. The nausea and vomiting may have been due to the adverse effects of both theophylline and tiabendazole. 

---