Thyroglobulin gene expression

G6rard, CM., Ro er, P.P., Dumont, J.E., 1989, Thyroglobulin gene expression as a differentiation marker in primary cultures of calf thyroid cells. Mol. Cell. Endocrinol. 61 23. 

Thyroid-specific genes, Tg (thyroglobulin) and TPO (thyroperoxidase), require both Pax-8 and TTF-1 for maximal gene expression (Kogai et al, 2006). A critical role of Pax-8 for TSH regulation of NIS through the NUE has been established (Ohno et al, 1999 Taki et al., 2002), while the role of TTF-1 in human NIS gene expression is likely to be less important. 

Other important monitoring parameter for thyroid carcinoma is the presence of tumor cells in bone marrow or the circulation of tumor cells in peripheral blood. For the detection of these tumor cells, molecular methods based on the detection of tissue-specific gene expression are developed. The most efficient molecular marker is mRNA encoding to the thyroid-specific hormone thyroglobulin (Tg), a further target is mRNA encoding specific enzymes involved in the synthesis of thyroid hormones such as thyroid peroxidase (TPO). Thyroid transcription factor-1 (TTF-1) is another thyroid-specific marker, which can be used for the diagnosis of thyroid tumors. 

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