Thrombospondin fibrinogen

Bacon-Baguley, T., Ogilvie, M. L., Gartner, T. K., and Walz, D. A. (1990). Thrombospondin binding to specific sequences within the A alpha- and B beta-chains of fibrinogen. J. Biol. Chem. 265, 2317-2323. 

Note CO — collagen FB — fibrinogen FN — fibronectin LM — laminin LPS — lipopolysaccha-ride TSP — thrombospondin VN — vitronectin vWF — von Willebrand factor. 

The extracellular domains of integrins interact with a variety of profeins of the extracellular matrix. These include fibronectin, fibrinogen, vifronecfin, collagen, and entacfin. Other large cell surface adhesins include laminin and osteopontin (Chapfer 8), thrombospondin, von Willebrand factor, and related proteins. These adhesins appear to depend upon the sequence Arg-Gly-Asp (RGD), which binds nonco-valently to integrins, which act as cell-surface receptors. See also Chapter 12, Section C,9. 

The second approach includes native long chain of ECM proteins as well as short peptide sequences derived from intact ECM proteins that are able to interact specifically with cell receptors and to confer appropriate functions to the biomaterials [102]. The most studied class of cell-adhesive molecules comprises ECM-soluble serum proteins, including fibronectin (FN), vitronectin (VN), collagen families, thrombospondin, osteopontin, fibrinogen, von Willebrand factor and laminin (LN) [87]. 

Adapted from Albelda, S.M. and Buck, C.A., FASEB J. 4, 2868, 1990. With permission and Hynes, R.O. and Lander, A.D., Cell 68, 303, 1992. With permission. LM laminin, COL collagens, FN fibronectin, VN vitronectin, FB fibrinogen, VWF von Willebrand Factor, TSP thrombospondin, C3bi breakdown product of third component of complement, FN-alt alternatively spliced fibronectin. DGEA, RGD, REDV, PHSRN, and GPRP are amino acid sequences. 

P3 olib Collagens, fibronectin, vitronectin, fibrinogen, thrombospondin... 

---