Third Generation 3-Blockers

Hoping to avoid such side effects as the sleep disruption and the occasional cardiac complications of the tricyclic antidepressants, and following the principle that clean drugs are theoretically preferable to dirty ones, the pharmaceutical industry has developed the selective serotonin reuptake blockers, a third generation of chemical agents to relieve depression. 

Ignarro LJ. Experimental evidences of nitric oxide-dependent vasodilatory activity of nebivolol, a third-generation beta-blocker. Blood Press Suppl. 2004 ... 

Lercanidipine is a third-generation dihydropyridine for once-daUy dosing in hjrpertension. It has similar antihypertensive efficacy and tolerability to other calcinm channel blockers (1). 

Low molecular weight heparins Extended spectmm penicillins First-generation cephalosporins Second-generation cephalosporins Third-generation cephalosporins Proton pump inhibitors blockers 5HT3 inhibitors Fluroquinolones Oxazolidinones/streptagramins Parenteral amino acids Sedative hypnotics Enteral feedings Insulins... 

Third generation P-blockers also cause peripheral vasodilation and do not adversely affect plasma lipid profiles. An example is celiprolol. 

Nonselective /3 blockers with additional actions Third generation ... 

The wisdom and skill of the medicinal chemist further, promulgated the on-going research through the extension tactics that essentially incorporated the strategical addition of arylalkyl functional moieties attached to the terminal N-atom thereby producing a new series of third generation P-blockers that get ultimately bound to the Pj-receptor by means of an additional H-bonding interaction. 

A few typical examples of the third generation P-blockers are discussed below namely Epanolol ... 

DiNicolantonio JJ, Hackam DG. Carvedilol a third-generation beta-blocker should be a first-choice beta-blocker. Expert Rev Cardiovasc Ther January 2012 10(l) 13-25. 

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