Third generation P-blockers

Third generation P-blockers also cause peripheral vasodilation and do not adversely affect plasma lipid profiles. An example is celiprolol. 

The wisdom and skill of the medicinal chemist further, promulgated the on-going research through the extension tactics that essentially incorporated the strategical addition of arylalkyl functional moieties attached to the terminal N-atom thereby producing a new series of third generation P-blockers that get ultimately bound to the Pj-receptor by means of an additional H-bonding interaction. 

A few typical examples of the third generation P-blockers are discussed below namely Epanolol ... 

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