Thiolated poly polymer

W. R Wuelfing, S. M. Gross, D. T. Miles, and R. W. Miuray, Nanometer gold elusters proteeted by surfaee-bound monolayers of thiolated poly( ethylene glyeol) polymer eleetrolyte, J. Am. Chem. Soc., 120 (1998) 12696-12697. 

Thiolated mucoadhesive polymers are synthesized by a covalent attachment between a cysteine (Cys) residue and a polymer of choice, such as polycarbo-phil [46], poly(acrylic acid) [47], and chitosan [48]. These polymers are known as a new generation of mucoadhesive polymers. These moderen class of polymers contain a carbodiimide-mediated thiol bond which exhibit mnch improved bioadhesive properties. 

Nanometer gold clusters protected by surface-bound monolayers of thiolated poly(ethyleneglycol) polymer electrolyte. 12 12696-12697. 

In addition to chemical and electrochemical synthesis, other polymerization methods such as photochemical synthesis, emulsion, and pyrolysis have been reported [58, 63]. In a recent study, a self-assembled monolayers (SAMs) method has been used to deposit thiolated poly(alkylthiophene)s and functionalized alka-nethiols [82]. The authors claimed that resulting polymers have low impedance at 1 kHz and are more robust and better controlled in their composition than existing electrodeposited conductive polymer coatings. 

For example, Wuelfing et al. reported on the synthesis of Au NPs using the thiolated polymer, a-methoxy-co-mercapto-poly(ethylene glycol) (PEG-SH), as stabilizer in a modification of the Brust-Schiffrin method using a 1/12 polymer thiol/ AuC14 ratio. Transmission electron microscopy showed that the product had modestly polydisperse Au cores of average diameter 2.8 1 nm. This nanomaterial led to characteristics uniquely different from alkanethiolate MPCs, notably aqueous solubility, thermal and chemical stability, ligand footprint size, and ionic conductivity [66]. 

Marschiiz, M.K. and Bernkop-Schnirch, A., Thiolated polymers self-crosslinking properties of thi-olated 450 kDa poly(acrylic acid) and their in uence on mucoadhdsim l. Pharm. Sci., 15, 387,... 

In a recent study, some authors proposed the employment of thiolated polymers obtained by the immobilization of thiol groups on well-established multifunctional polymers such as poly(acrylates) and chitosans as functional agents having mucoadhesive, penetration enhancement, and enzyme-inhibiting properties [94,95]. 

Poly(acrylic acid)-cysteine and chitosan-4-thiobulylamidine were evaluated as anionic and cationic polymers for the preparation of a DDS for riboflavin-S -monophosphate sodium salt dihydrate as a model drug. The particles had a mean diameter of 336.5 16.5 and 396.3 17.0 nm and a zeta potential of - 20.0 1.0 and -I- 27.2 0.5 mV, respectively. It was found that glutathione in combination with thiomers has a significant influence for increasing permeation, and that thiolated particles of both anionic and cationic polymers had improved mucoadhesive and controlled release properties. Therefore, they can be potentially applied as gastroretentive delivery systems. ... 

Catalyst MH-3, prepared from surfactant 6, was more active, and catalyst MH-2, prepared from surfactant 5, was less active than MH-1. We are continuing study of the oxidation kinetics to understand better the mechanism of oxidation. As with soluble poly(vinylamine) and ionene polymers containing CoPcTs, the mechanism does appear to involve Ae thiolate anion, and the rates of reaction are not simply dependent on the first power of CoPcTs concentration. There is evidence for formation of hydrogen peroxide during the CoPcTs-catalyzed autoxidation of mercaptoethanol. 4>5l At this time we do not know if there are significant differences in the mechanisms of autoxidation of mercaptoethanol catalyzed by polyelectrolytes and autoxidation of 1-decanethiol catalyzed by cationic latexes. 

Atyabi F, Moghaddam FA, Dinarvand R, Zohuriaan-Mehr MJ, Ponchel G. Thiolated chitosan coated poly hydroxyethyl methacrylate nanoparticles Synthesis and characterization. Carbohydr Polym. 2008 74(l) 59-67. 

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