Thio-TEPA

Trade Name(s) D Thiotepa "Lederle" GB (Lederle) I F Thiotepa Lederle (Lederle) Thio-Tepa (Lederle) wfm Onco-Tiotepa (Simes) wfm J Tespamin (Sumitomo) USA Thioplex (Immunex)... [Pg.2025]

VATH Vinblastine, daunomycin, Thio-TEPA, Halotestin Breast cancer... [Pg.235]

Thiopental Thio-TEPA Thrombin Thyroxine Tiagabine Ticarcillin Ticlopidine Timolol Tinidazol Tinzaparin ... [Pg.348]

Thiotepa Lederle Thio-TEPA Trimysten Clotrimazole... [Pg.366]

Cyclophosphamide (72) was made as a latent form of nitrogen mustard with fairly low toxicity. It undergoes oxidation by microsomes in the liver and then breaks down to give much more reactive derivatives of 2,2 -dichlorodiethylamine (Scheme 3). Several aziridines are used as alkylating agents. They include triethylenemelamine (73), triaziquone (74), TEPA (triethylenephosphoramide) (75 X = O) and thio-TEPA (75 X = S). Ethylene oxide... [Pg.157]

D Thiotepa "Lederle" GB Thio-Tepa (Lederle) wfm J Tespamin (Sumitomo)... [Pg.2025]

Thiotepa Lederle Thio-TEPA Tryptizol Amitriptyline... [Pg.367]

Thio-TEPA Thiotepa Lederle Valproic acid Depakene ... [Pg.379]

Examples include busultan, carmustine, chlorambucil, cyclophosphamide, ifosfamide, lomus-tine, melphalan, mustine (mechlorethamine), thio-tepa, treosulfan. [Pg.606]

However, in a phase II stndy of the combination of novobiocin and high-dose cyclophosphamide and thio-tepa, followed by antologons bone marrow support in women with chemosensitive advanced breast cancer, there was no significant increase in progression-free snr-vival and overall snrvival compared with historical controls treated with high-dose alkylating drugs alone (3). [Pg.2585]

Several members of this dual antagonist series showed marked antitumor activities in experimental animals and in man. In both the pharmacologic and subsequent clinical studies, 72 and 73 (in which the aziridine ring carbons are unsubstituted methylene groups) were found to behave essentially like the typical ethylenimine-type alkylating agents (e.g., TEPA, or thio-TEPA). [Pg.91]

Methylisocytosine (LVIII, superacyl) has been reported to stimulate antibody production in rabbits to an extent greater than with a vaccine alone [354]. It also markedly reduced the development of pulmonary adenoma at 100 mg/kg per day for 10, 25 or 50 days s.c. or p.o. to mice, following a single i.p. injection of urethan. 5-Hydroxy-6-methylisocytosine had the same effect [19]. In tests on the effect of pyrimidines on reticuloendothelial functions in mice, the absorptive capacity of this system increased with 5-(hydroxymethyl)uracil or with 6-methylisocytosine. The effect was most pronounced when superimposed on cortisone inhibition [355]. When administered subcutaneously to mice, 6-methylisocytosine increased the inhibitory effect of thio-TEPA on the growth of Ehrlich tumours in mice. It is believed that this pyrimidine prevents the development of metastases [356]. [Pg.89]

Alkylating Agents are contlnuii to receive attention as antlneoplastlc agents. In view of the favorable therapeutic indices of some aromatic carbamate mustards in the Walker 256 system, several new compounds were prepared, wherein the jD-phenyl N- phenylcaibamate moiety was linked to bis (1-aziridinyl)- and bis (2,2-dimethyl-l-aziridinyl)phosphinate. No improvement of the chemotherapeutic index was achieved by this modification . On the other hand, replacement of one ethyleneimine group in thio-TEPA with a methyl substituted oxypiperidine moiety 5 (Vin), furnished a compound which reportedly was... [Pg.145]

M. than equivalent doses of thio-TEPA. Steroidal allg lating... [Pg.145]

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