Thiabendazole structure

Since all members of the benzimidazole anthelminthics except thiabendazole contain a benzimidazole carbamate moiety, attempts have been made to produce antibodies recognizing this structure (19). Most successful was an approach in which a carboxylated analogue of albendazole was used as hapten and coupling to the carrier protein was performed using (V-hydroxysuccinimide and morpholi-noethyl isocyanide in the presence of dimethylamino pyridine. 

The structure of (9-methyladenine)ZnCl2 is polymeric each zinc ion is tetrahedrally co-ordinated to two chlorine atoms (Zn—Cl = 2.22 AX and to N(l) and N(7) of neighbouring adenine moieties (Zn—N = 2.05 A).Complexes of the stoicheiometry [ML3][C104]2[L = thiabendazole (1)] contain the metal in an octahedral co-ordination with the chelating ligand co-ordinated via the nitrogens of the imidazole and thiazole rings. 

The continuous use of o-phenylphenol, biphenyl, thiabendazole, benomyl, and sec-butyl amine for 20 years to control postharvest decay of citrus fruits has resulted 1n a serious problem of fungicide-resistance in Peniclllium digitatum and P. italicum. Fungicide-resistant Perilc1111 um Isolates are cross-resistant to structurally-related compounds and, 1n addition, may be resistant to two or more unrelated compounds. Biotypes of P. digitatum resistant to imazalil have been found recently in 19 packinghouses throughout California. 

All garden enthusiasts know about the nice autumn crocus (Colchicum autumnale), which flowers in late autumn. It is not difficult to understand that this very conspicuous plant profits by containing a strong poison that protects it from pathogens and herbivores. It contains colchicine, which is very toxic and has a complicated structure. The substance is well known to plant breeders because it is used to double the number of chromosomes artificially in plants. A synthetic benzimidazole derivative, l-methyl-3-dode-cylbenzimidazolium chloride, was developed in 1960 as a curative fungicide against apple scab. Thiabendazole, another synthetic benzimidazole derivative, has been used as an anthelmintic since 1962. 

Mechanism Thiabendazole is a structural congener of mebendazole and has a similar action on microtubules. 

Thiabendazole and permethrin structures (see Section 12.6.2.1.2), salicylic acid structure (see Section 8.2.6.1.6). "Drugs used against external (ectoparasitica) and internal (endoparasitica) parasites. 

---