Therapeutic Delivery of CO

Adjei, H. (1997). Inhalation Delivery of Therapeutic Peptides and Proteins. J.A. Majors Co., Atlanta, GA. 

Chemical PEs have recently been studied for increasing transdermal delivery of ASOs or other polar macromolecules [35]. Chemically induced transdermal penetration results from a transient reduction in the barrier properties of the stratum corneum. The reduction may be attributed to a variety of factors such as the opening of intercellular junctions due to hydration [36], solubilization of the stratum corneum [37, 38], or increased lipid bilayer fluidization [39, 40]. Combining various surfactants and co-solvents can be used to achieve skin penetration, purportedly resulting in therapeutically relevant concentrations of ASO in the viable epidermis and dermis [41]. In summary, it appears feasible to deliver ASO to the skin using a number of different delivery techniques and formulations. 

The selective activation of compounds with potential therapeutic effects and the controlled delivery of bioactive molecules triggered by light are topics of intensely growing interest (6,197-200). Besides the search for light-sensitive prodrugs activated by photochemical cleavage, isomerization or photoredox processes (201-203), especially the release of small molecules such as NO, CO, CS2, and H2S, have attracted a lot of interest in the past years (204-208). 

Wiradharma N, Tong YW, Yang Y-Y (2009) Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect. Biomaterials 30 3100-3109... 

---