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Therapeutic chelating agents

In some cases, the metal-mobilizing effect of a therapeutic chelating agent may not only enhance that metal s excretion—... [Pg.1238]

The tripeptide amide L-Pro-L-Leu-Glyamide (melanostatin) is a hypothalamic hormone and an effective therapeutic chelating agent. Its chelating properties have been examined by Kozlowski and his co-workers59 because of thdr interest in proline-containing peptides (Chapter 20.2). With Cu11... [Pg.966]

Jones, M. M.-.Therapeutic chelating agents, in Metal Ions in Biological Systems 16, p. 1 (ed. Sigel, H.), New York, Marcel Dekker, Inc. 1980... [Pg.133]

Jones MM. 1991. New developments in therapeutic chelating agents as antidotes for metal poisoning. CRC Crit Rev Toxicol 21(3) 209-233. [Pg.618]

Table 7.1 Important criteria to be considered on selecting a therapeutic chelating agent... Table 7.1 Important criteria to be considered on selecting a therapeutic chelating agent...
M.M. Jones, The Design of Therapeutic Chelating Agents , J. Coord. Chem., 1991, 23, 187-200. [Pg.97]

As with histidine, cysteine is a major metal binding site in proteins. Penicillamine (j8, -di-methylcysteine), a degradation product of penicillin, finds use as a therapeutic chelating agent (see Volume 6, Chapter 62.2). Both Cys and Pen have three dissociable protons (pAT values approximately 2, 8 and 10) with Pen being the slightly more basic. Both amino acids undergo oxidation to the disulfide form (equation 6), a reaction which is catalyzed by metal ions, notably Cu and Fe . [Pg.1394]

LD50 Values of Therapeutic and Non-therapeutic Chelating Agents... [Pg.338]

Figure 15.23 shows an aerial view of a cyanide pond used for the extraction of gold. Therapeutic Chelating Agents... [Pg.794]

Jokstad A, Thomassen Y, Bye E, Clench-Aas J, Aaseth J (1992) Dental amalgam and mercury. Pharmacol Toxicol 70 308-313 Jones MM (1991) New developments in therapeutic chelating agents as antidotes for metal poisoning. CRC Crit Rev Toxicol 21 209-233 Jones SG, Basinger MA, Jones MM, Gibbs SG (1982) A comparison of diethyldi-thiocarbamate and EDTA as antidotes for acute cadmium intoxication. Res Commun Chem Pathol Pharmacol 38 271-278 Joyce DA (1989) o-Penicillamine pharmacokinetics and pharmacodynamics in man. Pharmacol Ther 42 405-427... [Pg.302]

Extensive updating of therapeutic chelating agents effective against lead, arsenic, and mercury poisoning, as well as Wilson s disease... [Pg.661]

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See also in sourсe #XX -- [ Pg.898 ]

See also in sourсe #XX -- [ Pg.978 ]

See also in sourсe #XX -- [ Pg.703 ]



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