Therapeutic applications of injectable nano-carriers

As a result, a vast number of nano-carriers have been used for the tumour-targeted delivery of active principles they include liposomes, micelles, polymeric nanoparticles, solid lipid nanoparticles (SLN), dendrimers, nanoshells, and magnetic nanoparticles. Examples of nano-carriers with proven clinical efficacy are reported in Table 12.2. 

Despite the relatively large number of clinically tested nano-carriers, very few of them feature ligands for a targeted action drawbacks that have hindered these carriers commonly include the expression of the targeted receptors by non- 

Formulation Carrier Therapeutic agent Targeting (receptor) Tumour Status 

Doxil Liposome Doxorubicin Passive Breast, ovarian FDA approved  

Daunoxome Liposome Daunorubicin Passive Kaposi sarcoma FDAapproved -  

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