Therapeutic agent-carriers

Therapeutic agent carrier Af-Vinylpyrrolidone U.S.S.R. 373,278 1973 Institute High Molecular... 

The choice of a macromolecular carrier depends on the intended clinical objectives and the nature of the therapeutic agents being used. In general, the properties of an ideal soluble carrier system include the following... 

The transport across cell walls is often a major problem for therapeutic agents. The possibility of designing drugs chemically linked to sucrose, which would act as a carrier, offers a means of overcoming this limitation. 

Liposomes are colloidal particles that can be prepared with (phospho)-lipid molecules derived from either natural sources or chemical synthesis (recently reviewed by Lian and Ho [14]). The potential application of liposomes as biodegradable or biocompatible drug carriers to enhance the potency and reduce the toxicity of therapeutic agents was recognized in 1960. In the 1960s and 1970s various methods for liposome preparation were developed as... 

An effective therapeutic agent must also have the ability to reach its target sequence in vivo. In order to enhance membrane transport, antisense oligonucleotides are frequently modified by covalent attachment of carrier molecules or lipophilic groups. 

Wajs, G., and J.C. Meslard. 1986. Release of therapeutic agents from contact lenses. Crit Rev Ther Drug Carrier Syst 2 275. 

Mohler, K, M., Torrance, D. S., Smith, C. A., Goodwin, R. G., Stremler, K. E., Fung, V. P., Madani, H., Widmer, and M. B. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists./. Immunol. 151, 1548-1561. 

A polyethylene glycol-conjugated hemoglobin derivative and carbon monoxide carrier, CO-MP4, is able to deliver CO to the circulation and reduces ischemia/ reperfusion injury in rats, providing the first evidence for this drug as a CO therapeutic agent [191, 192]. 

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