Therapeutic agents cellulose acetate

Taepaiboon, P., Rungsardthong, U., and Supaphol, P. (2007) Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur. J. Pharm. Biopharm., 67, 387—397. 

The antiviral properties of anionic polymers have recently received a lot of attention as agents to protect against infection with sexually transmitted diseases. Due to the cationic nature of most viruses, several anionic polymers are known to bind viruses. As early as the 1960s, researchers had studied the anti-viral properties of a variety of synthetic polymers [118]. However, not all anionic polymers inactivate viruses. Several classes of anionic polymers have been studied for their ability to inactivate the HIV virus. These polymers include poly(styrene-4-sulfonate), 2-naphthalenesulfonate-formaldehyde polymer, and acrylic acid-based polymers. Certain chemically modified natural polymers (i.e., semisynthetic) such as dextrin/dextran sulfates, cellulose sulfate, carrageenan sulfate, and cellulose acetate phthalate have also been investigated for this purpose. Of a number of such anionic polymers that have shown in-vitro and in vivo anti-HIV activity, a couple of polymeric drug candidates have proceeded to early stage human clinical trials for the evaluation of safety/tolerability [119]. While most of these have shown the desired tolerability and safety, further clinical trials are necessary to discern the therapeutic benefit and see if anionic polymers will be applicable as anti-HIV therapies. 

---